Unstable cytokeratins are associated with tumor transformation in the development of
human hepatocellular carcinoma. We previously demonstrated that the cytokeratin 18 was …

Background: Aberrant histone deacetylase expression may cause imbalance between
acetylation and deacetylation of histone and play roles in tumor transformation. We found …

Background: Previously we found some low molecular weight proteins identified as histone
in hepatocelluar carcinoma. Our objective was to clarify whether the co-immunoprecipitation …

Analysis of acetylation and tri-methylation of the same residue of histone molecules might
identify a subset of hepatocellular carcinoma (HCC) with aggressive behavior. In the present …

Chromatin remodeling through histone modification is an important mechanism of
epigenetic gene dysregulation in human cancers. However, little is known about global …

In eukaryotes, histones and their variants are essential for chromatin structure and function;
both play important roles in the regulation of gene transcription, as well as the development …

Cells respond to various environmental factors such as nutrients, food intake, and drugs or
toxins by undergoing dynamic epigenetic changes. An imbalance in dynamic epigenetic …

To investigate whether alterations in histone modifications occur in esophageal squamous
cell carcinoma (ESCC), we measured histone H3/H4 acetylation and H3K4/H3K27 …

Chromatin alterations brought by histone variants and modifications potentially regulate
gene transcription from tumor initiation to progression. Histone H3. 3 variant is one such …

Background Histone acetylation modification is one of the most common epigenetic methods
used to regulate chromatin structure, DNA repair, and gene expression. Existing research …