Drug resistance represents a major obstacle in cancer chemotherapy. As chemically
characterized compounds derived from plants used in traditional Chinese medicine (TCM) …

Loss of function of DNA repair (DNAR) genes is associated with genomic instability and
cancer predisposition; it also makes cancer cells reliant on a reduced set of DNAR pathways …

Natural antioxidants derived from plants exert various physiological effects, including
antitumor effects. However, the molecular mechanisms of each natural antioxidant have not …

Targeting synthetic lethality in DNA repair pathways has become a promising anti-cancer
strategy. However little is known about such interactions with regard to the nucleotide …

Computational analysis of cancer pharmacogenomics data has resulted in biomarkers
predictive of drug response, but the majority of response is not captured by current methods …

Cancer is a disease caused by a series of genetic and epigenetic alterations. Therefore,
agents targeting the genetic and/or epigenetic machinery offer potential for the development …

Resistance to current cancer treatments is an important problem that arises through various
mechanisms, but one that stands out involves an overexpression of several factors …

BACKGROUND: The nucleotide excision repair pathway is crucial for cellular DNA integrity
and the ERCC1 helicase is also potentially involved in resistance to platinum-based …

The evolving field of cancer pharmacogenomics uses genetic profiling to predict the
response of tumor and normal tissue to therapy. The narrow therapeutic index and …

Nucleotide excision repair (NER) is a multi-enzyme DNA repair pathway in eukaryotes.
Several NER genes in this pathway including XPB, XPD, XPA and ERCC-1 have been …