Co-occurrent alterations of Alzheimer's genes and prostate cancer genes in prostate cancer

S Lehrer, PH Rheinstein - Cancer Genomics & Proteomics, 2020 - cgp.iiarjournals.org
Background: Androgen deprivation therapy (ADT) is extensively employed in treatment of
prostate cancer. Some studies have found increased risk of Alzheimer's disease and …

Alzheimer gene BIN1 may simultaneously influence dementia risk and androgen deprivation therapy dosage in prostate cancer

S Lehrer, PH Rheinstein - American journal of clinical oncology, 2020 - journals.lww.com
Background: Androgen deprivation therapy (ADT) is extensively used in prostate cancer. Yet
the risk of impaired cognition or Alzheimer disease (AD) in men with prostate cancer …

A study of gene expression by RNA-seq in patients with prostate cancer and in patients with Parkinson disease: An example of inverse comorbidity

P Pepe, S Vatrano, R Cannarella, AE Calogero… - Molecular Biology …, 2021 - Springer
Abstract Background Prostate cancer (PCa) is one of the leading causes of death in Western
countries. Environmental and genetic factors play a pivotal role in PCa etiology. Timely …

Increased cytokine gene expression and cognition risk associated with androgen deprivation therapy

S Verma, PP Kushwaha, E Shankar, LE Ponsky… - The …, 2022 - Wiley Online Library
Background Androgen deprivation therapy (ADT) is a standard treatment modality for locally
advanced, high‐risk, and metastatic hormone‐sensitive prostate cancer. Long‐term ADT …

[HTML][HTML] Transcriptomic and genetic associations between Alzheimer's disease, Parkinson's disease, and cancer

J Fores-Martos, C Boullosa, D Rodrigo-Dominguez… - Cancers, 2021 - mdpi.com
Simple Summary Epidemiological studies have identified a link between neurodegenerative
disorders and a reduced risk of overall cancer. Increases and decreases in the risk of site …

[HTML][HTML] Discovering gene signature shared by prostate cancer and neurodegenerative diseases based on the bioinformatics approach

Q Su, B Dai, H Zhang, S Zhang - Computational and Mathematical …, 2022 - hindawi.com
Background. Prostate cancer (PCa) is one of the highest frequent malignant tumors with very
complicated pathogenesis. Genes of neurodegenerative diseases can influence tumor …

[HTML][HTML] Deciphering the enigmatic crosstalk between prostate cancer and Alzheimer's disease: a current update on molecular mechanisms and combination therapy

NK Poddar, D Agarwal, Y Agrawal… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Alzheimer's disease (AD) and prostate cancer (PCa) are considered the leading causes of
death in elderly people worldwide. Although both these diseases have striking differences in …

Identification of critical pathways and hub genes in TP53 mutation prostate cancer by bioinformatics analysis

J Sun, K Zhang, Z Cai, K Li, C Zhao, C Fan… - Biomarkers in …, 2019 - Future Medicine
Aim: The TP53 mutant is one of the most common mutant genes in prostate cancer.
Materials & methods: The RNA-seq data of prostate cancer was downloaded from TCGA …

[HTML][HTML] Integrated Bioinformatics Analysis Identified ASNS and DDIT3 as the Therapeutic Target in Castrate-Resistant Prostate Cancer

AR Jung, S Shin, MY Kim, US Ha, SH Hong… - International Journal of …, 2024 - mdpi.com
Many studies have demonstrated the mechanisms of progression to castration-resistant
prostate cancer (CRPC) and novel strategies for its treatment. Despite these advances, the …

[HTML][HTML] Identification of pathologic and prognostic genes in prostate cancer based on database mining

K Liu, Y Chen, P Feng, Y Wang, M Sun, T Song… - Frontiers in …, 2022 - frontiersin.org
Background: Prostate cancer (PCa) is an epithelial malignant tumor that occurs in the
urinary system with high incidence and is the second most common cancer among men in …