LKW, a Putative Dual-specificity Kinase which is Down-regulated in Several Invasive Systems
S Lösch, M Buchholz, TM Gress… - Cancer Genomics & …, 2004 - cgp.iiarjournals.org
Using Affymetrix GeneChip® arrays, we have established the transcriptional profiles of two
sublines of the human pancreatic adenocarcinoma cell lines SUIT-2, S2-007 (metastatic) …
sublines of the human pancreatic adenocarcinoma cell lines SUIT-2, S2-007 (metastatic) …
[HTML][HTML] Decreased LKB1 predicts poor prognosis in pancreatic ductal adenocarcinoma
JY Yang, SH Jiang, DJ Liu, XM Yang, YM Huo, J Li… - Scientific reports, 2015 - nature.com
Abstract Liver kinase B1 (LKB1) has been identified as a critical modulator involved in cell
proliferation and polarity. The purpose of the current study was to characterize the …
proliferation and polarity. The purpose of the current study was to characterize the …
Parallel hybridization analysis of multiple protein kinase genes: identification of gene expression patterns characteristic of human hepatocellular carcinoma
AP Tsou, KM Wu, TY Tsen, CW Chi, JH Chiu, WY Lui… - Genomics, 1998 - Elsevier
Hepatocellular carcinoma (HCC) is one of the major causes of human cancer deaths
worldwide. To identify alterations of the genetic program associated with human HCC, we …
worldwide. To identify alterations of the genetic program associated with human HCC, we …
Frequent alterations in the expression of serine/threonine kinases in human cancers
M Capra, PG Nuciforo, S Confalonieri, M Quarto… - Cancer research, 2006 - AACR
Protein kinases constitute a large family of regulatory enzymes involved in the homeostasis
of virtually every cellular process. Subversion of protein kinases has been frequently …
of virtually every cellular process. Subversion of protein kinases has been frequently …
[HTML][HTML] Analysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinome
S Kilpinen, K Ojala, O Kallioniemi - PloS one, 2010 - journals.plos.org
Kinases play key roles in cell signaling and represent major targets for drug development,
but the regulation of their activation and their associations with health and disease have not …
but the regulation of their activation and their associations with health and disease have not …
Genetic variants in the liver kinase B1‐AMP‐activated protein kinase pathway genes and pancreatic cancer risk
The liver kinase B1‐AMP‐activated protein kinase (LKB1‐AMPK) pathway has been
identified as a new target for cancer therapy, because it controls the glucose and lipid …
identified as a new target for cancer therapy, because it controls the glucose and lipid …
[HTML][HTML] Spatiotemporal proteomic analyses during pancreas cancer progression identifies serine/threonine stress kinase 4 (STK4) as a novel candidate biomarker for …
JE Mirus, Y Zhang, MA Hollingsworth, JL Solan… - Molecular & Cellular …, 2014 - ASBMB
Pancreas cancer, or pancreatic ductal adenocarcinoma, is the deadliest of solid tumors, with
a five-year survival rate of< 5%. Detection of resectable disease improves survival rates, but …
a five-year survival rate of< 5%. Detection of resectable disease improves survival rates, but …
Isolation of a growth factor stress-induced pancreatic Cancer sub-population: insight into changes due to micro-environment
B Baron, T Kitagawa, K Nakamura… - Cancer Genomics & …, 2015 - cgp.iiarjournals.org
Background: Micro-environment plays a crucial role in determining the phenotypes within a
tumor. Materials and Methods: In order to understand how the micro-environment affects …
tumor. Materials and Methods: In order to understand how the micro-environment affects …
Decreased expression of tumor-suppressor gene LKB1 correlates with poor prognosis in human gastric cancer
J Sun, B Ling, X Xu, R Ma, G Li, X Cao… - Anticancer …, 2016 - ar.iiarjournals.org
Background/Aim: The present report describes the correlation of liver kinase B1 (LKB1)
expression with tumorigenesis and prognosis in gastric cancer. Materials and Methods …
expression with tumorigenesis and prognosis in gastric cancer. Materials and Methods …
[HTML][HTML] LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap and β-catenin
LG Ma, SB Bian, JX Cui, HQ Xi… - International …, 2016 - spandidos-publications.com
Abstract Liver kinase B1 (LKB1) is known to suppress the proliferation, energy metabolism
and mesenchymal transition of various cancer cells, and is involved in the regulation of …
and mesenchymal transition of various cancer cells, and is involved in the regulation of …