Multisite tumor sampling reveals extensive heterogeneity of tumor and host immune response in ovarian cancer
S Lakis, V Kotoula, GA Koliou, I Efstratiou… - Cancer Genomics & …, 2020 - cgp.iiarjournals.org
Background/Aim: Ovarian cancer (OVCA) is characterized by genomic/molecular intra-
patient heterogeneity (IPH). Tissue histology and morphological features are surrogates of …
patient heterogeneity (IPH). Tissue histology and morphological features are surrogates of …
[PDF][PDF] Interfaces of malignant and immunologic clonal dynamics in ovarian cancer
High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with
widespread but non-random patterns of disease dissemination. We investigated whether …
widespread but non-random patterns of disease dissemination. We investigated whether …
[HTML][HTML] Combining mass cytometry data by CyTOFmerge reveals additional cell phenotypes in the heterogeneous ovarian cancer tumor microenvironment: a pilot …
LCV Thomsen, K Kleinmanns, S Anandan… - Cancers, 2023 - mdpi.com
Simple Summary High-grade serous ovarian cancer (HGSOC) has a dismal prognosis, but
its tumor microenvironment (TME), which impacts disease progression and prognosis, is …
its tumor microenvironment (TME), which impacts disease progression and prognosis, is …
[HTML][HTML] Phenotypic characterization by mass cytometry of the microenvironment in ovarian cancer and impact of tumor dissociation methods
S Anandan, LCV Thomsen, SE Gullaksen, T Abdelaal… - Cancers, 2021 - mdpi.com
Simple Summary High-grade serous ovarian cancer (HGSOC) is the deadliest
gynecological malignancy. Despite increasing research on HGSOC, biomarkers for …
gynecological malignancy. Despite increasing research on HGSOC, biomarkers for …
Measurement of ovarian tumor immune profiles by multiplex immunohistochemistry: implications for epidemiologic studies
CA Hathaway, JR Conejo-Garcia, BL Fridley… - … Biomarkers & Prevention, 2023 - AACR
Background: Despite the immunogenic nature of many ovarian tumors, treatment with
immune checkpoint therapies has not led to substantial improvements in ovarian cancer …
immune checkpoint therapies has not led to substantial improvements in ovarian cancer …
[HTML][HTML] Exploring the tumor micro-environment in primary and metastatic tumors of different ovarian cancer histotypes
B Xie, S Olalekan, R Back, NA Ashitey… - Frontiers in Cell and …, 2024 - frontiersin.org
Ovarian cancer is a highly heterogeneous disease consisting of at least five different
histological subtypes with varying clinical features, cells of origin, molecular composition …
histological subtypes with varying clinical features, cells of origin, molecular composition …
Decoding transcriptomic intra‐tumour heterogeneity to guide personalised medicine in ovarian cancer
The evaluation of intra‐tumour heterogeneity (ITH) from a transcriptomic point of view is
limited. Single‐cell cancer studies reveal significant genomic and transcriptomic ITH within a …
limited. Single‐cell cancer studies reveal significant genomic and transcriptomic ITH within a …
[PDF][PDF] Extensive three-dimensional intratumor proteomic heterogeneity revealed by multiregion sampling in high-grade serous ovarian tumor specimens
AL Hunt, NW Bateman, W Barakat, S Makohon-Moore… - Iscience, 2021 - cell.com
Enriched tumor epithelium, tumor-associated stroma, and whole tissue were collected by
laser microdissection from thin sections across spatially separated levels of ten high-grade …
laser microdissection from thin sections across spatially separated levels of ten high-grade …
Exploring the tumor micro-environment in ovarian cancer histotypes and tumor sites
Ovarian cancer is a highly heterogeneous disease consisting of at least five different
histological subtypes with varying clinical features, cells of origin, molecular composition …
histological subtypes with varying clinical features, cells of origin, molecular composition …
[HTML][HTML] Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors
IG Funingana, JS Bedia, YW Huang… - Seminars in …, 2023 - Springer
High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy. Its
diagnosis at advanced stage compounded with its excessive genomic and cellular …
diagnosis at advanced stage compounded with its excessive genomic and cellular …