Background/Aim: Primary tumors display a great level of intra-tumor heterogeneity in breast
cancer. The current lack of prognostic and predictive biomarkers limits accurate stratification …

Breast cancer tumors are composed of heterogeneous cell populations. These populations
display a high variance in morphology, growth and metastatic propensity. They respond …

Introduction Only a limited number of tumor markers for breast cancer are currently
available. Antibodies to tumor-associated proteins may expand the number of available …

Background There is much evidence that tumor cells elicit a humoral immune response in
patients. In most cases, the presence of antibodies in peripheral blood is detected only in …

High-throughput molecular profiling techniques are helpful in the diagnosis of multifactorial
disease. In this study, a cDNA-phage-displayed protein microarray using phage particles …

Recent evidence suggests that most malignancies are driven by “cancer stem cells” sharing
the signature characteristics of adult stem cells: the ability to self renew and to differentiate …

To generate a panel of antibodies binding human breast cancers, a human single chain Fv
phage display library was selected for rapid internalization into the SK-BR-3 breast cancer …

Phage display is a well-established procedure to isolate binders against a wide variety of
antigens that can be performed on purified antigens, but also on intact cells. As selection …

Tumour-associated cell surface markers are potential targets for antibody-based therapies.
We have obtained a panel of myeloid cell binding single chain variable fragments (scFv) by …

The majority of therapeutic antibodies, bispecific antibodies, and chimeric antigen receptor
(CAR) T cells in cancer therapy are based on an antibody or antibody fragment that …