DNA damage response: the players, the network and the role in tumor suppression
R Rai, G Peng, K Li, SY Lin - Cancer Genomics & Proteomics, 2007 - cgp.iiarjournals.org
One of the most common features of cancer is genetic instability. In response to numerous
DNA-damaging insults, normal cells have evolved a complex mechanism to monitor and …
DNA-damaging insults, normal cells have evolved a complex mechanism to monitor and …
[BOOK][B] The DNA damage response: implications on cancer formation and treatment
The field of cellular responses to DNA damage has attained widespread recognition and
interest in recent years commensurate with its fundamental role in the maintenance of …
interest in recent years commensurate with its fundamental role in the maintenance of …
Causes and consequences of the DNA damage response
A Nussenzweig - Cell Cycle, 2007 - Taylor & Francis
A prerequisite for maintaining genome stability in all cell types is the accurate repair and
efficient signaling of DNA double strand breaks (DSBs). It is believed that DSBs are initially …
efficient signaling of DNA double strand breaks (DSBs). It is believed that DSBs are initially …
Molecular mechanisms involved in initiation of the DNA damage response
KJ Barnum, MJ O'Connell - Molecular & Cellular Oncology, 2015 - Taylor & Francis
DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must
respond to this damage by activating repair and cell cycle checkpoint pathways. The …
respond to this damage by activating repair and cell cycle checkpoint pathways. The …
Dealing with DNA damage: relationships between checkpoint and repair pathways
DO Warmerdam, R Kanaar - Mutation Research/Reviews in Mutation …, 2010 - Elsevier
Cell cycle checkpoint activation and DNA repair pathways govern genomic stability after
genotoxic stress. Genotoxic insult results in activation of an interwoven network of DNA …
genotoxic stress. Genotoxic insult results in activation of an interwoven network of DNA …
Regulation of DNA repair throughout the cell cycle
D Branzei, M Foiani - Nature reviews Molecular cell biology, 2008 - nature.com
The repair of DNA lesions that occur endogenously or in response to diverse genotoxic
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …
DNA repair dysregulation from cancer driver to therapeutic target
NJ Curtin - Nature Reviews Cancer, 2012 - nature.com
Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …
DNA damage response (DDR), is associated with a predisposition to cancer and affects …
DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
Several newly identified tumor suppressor genes including ATM, NBS1, BRCA1 and BRCA2
are involved in DNA double-strand break repair (DSBR) and DNA damage-induced …
are involved in DNA double-strand break repair (DSBR) and DNA damage-induced …
Mammalian DNA damage response pathway
Z Lou, J Chen - Genome Instability in Cancer Development, 2005 - Springer
The genome of an organism is under constant attack from exogenous and endogenous DNA
damaging factors such as radiation, carcinogens and reactive radicals. Cells have …
damaging factors such as radiation, carcinogens and reactive radicals. Cells have …
DNA damage checkpoints: from initiation to recovery or adaptation
J Bartek, J Lukas - Current opinion in cell biology, 2007 - Elsevier
In response to diverse genotoxic stresses, cells activate DNA damage checkpoint pathways
to protect genomic integrity and promote survival of the organism. Depending on DNA …
to protect genomic integrity and promote survival of the organism. Depending on DNA …