DNA damage response: the players, the network and the role in tumor suppression

R Rai, G Peng, K Li, SY Lin - Cancer Genomics & Proteomics, 2007 - cgp.iiarjournals.org
One of the most common features of cancer is genetic instability. In response to numerous
DNA-damaging insults, normal cells have evolved a complex mechanism to monitor and …

[BOOK][B] The DNA damage response: implications on cancer formation and treatment

KK Khanna, Y Shiloh - 2009 - Springer
The field of cellular responses to DNA damage has attained widespread recognition and
interest in recent years commensurate with its fundamental role in the maintenance of …

Causes and consequences of the DNA damage response

A Nussenzweig - Cell Cycle, 2007 - Taylor & Francis
A prerequisite for maintaining genome stability in all cell types is the accurate repair and
efficient signaling of DNA double strand breaks (DSBs). It is believed that DSBs are initially …

Molecular mechanisms involved in initiation of the DNA damage response

KJ Barnum, MJ O'Connell - Molecular & Cellular Oncology, 2015 - Taylor & Francis
DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must
respond to this damage by activating repair and cell cycle checkpoint pathways. The …

Dealing with DNA damage: relationships between checkpoint and repair pathways

DO Warmerdam, R Kanaar - Mutation Research/Reviews in Mutation …, 2010 - Elsevier
Cell cycle checkpoint activation and DNA repair pathways govern genomic stability after
genotoxic stress. Genotoxic insult results in activation of an interwoven network of DNA …

Regulation of DNA repair throughout the cell cycle

D Branzei, M Foiani - Nature reviews Molecular cell biology, 2008 - nature.com
The repair of DNA lesions that occur endogenously or in response to diverse genotoxic
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …

DNA repair dysregulation from cancer driver to therapeutic target

NJ Curtin - Nature Reviews Cancer, 2012 - nature.com
Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

GK Dasika, SCJ Lin, S Zhao, P Sung, A Tomkinson… - Oncogene, 1999 - nature.com
Several newly identified tumor suppressor genes including ATM, NBS1, BRCA1 and BRCA2
are involved in DNA double-strand break repair (DSBR) and DNA damage-induced …

Mammalian DNA damage response pathway

Z Lou, J Chen - Genome Instability in Cancer Development, 2005 - Springer
The genome of an organism is under constant attack from exogenous and endogenous DNA
damaging factors such as radiation, carcinogens and reactive radicals. Cells have …

DNA damage checkpoints: from initiation to recovery or adaptation

J Bartek, J Lukas - Current opinion in cell biology, 2007 - Elsevier
In response to diverse genotoxic stresses, cells activate DNA damage checkpoint pathways
to protect genomic integrity and promote survival of the organism. Depending on DNA …