Co-culture with human breast adipocytes differentially regulates protein abundance in breast Cancer cells

RLI Crake, E Phillips, T Kleffmann… - Cancer Genomics & …, 2019 - cgp.iiarjournals.org
Background/Aim: Recent research highlights the role of cancer-associated adipocytes (CAA)
in promoting breast cancer cell migration, invasion and resistance to therapy. This study …

[HTML][HTML] Cancer-associated adipocytes in breast cancer: Causes and consequences

I Rybinska, N Mangano, E Tagliabue… - International journal of …, 2021 - mdpi.com
Breast cancer progression is highly dependent on the heterotypic interaction between tumor
cells and stromal cells of the tumor microenvironment. Cancer-associated adipocytes …

[HTML][HTML] Cancer-associated adipocytes and breast cancer: Intertwining in the tumor microenvironment and challenges for cancer therapy

C Wu, S Dong, R Huang, X Chen - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer is the most prevalent cancer in women worldwide, and it
exhibits a growing incidence. An increasing number of studies showed the complex …

[HTML][HTML] Adipocytes induce distinct gene expression profiles in mammary tumor cells and enhance inflammatory signaling in invasive breast cancer cells

A Nickel, C Blücher, OA Kadri, N Schwagarus… - Scientific reports, 2018 - nature.com
Obesity is a known risk factor for breast cancer. Since obesity rates are constantly rising
worldwide, understanding the molecular details of the interaction between adipose tissue …

[HTML][HTML] Intratumoral adipocyte-high breast cancer enrich for metastatic and inflammation-related pathways but associated with less cancer cell proliferation

Y Tokumaru, M Oshi, E Katsuta, L Yan… - International journal of …, 2020 - mdpi.com
Cancer-associated adipocytes are known to cause inflammation, leading to cancer
progression and metastasis. The clinicopathological and transcriptomic data from 2256 …

Adipocytes secretome from normal and tumor breast favor breast cancer invasion by metabolic reprogramming

M Zaoui, M Morel, L Louadj, N Ferrand… - Clinical and …, 2023 - Springer
Background Adipose tissue is a major component of breast stroma. This study focused on
delineating the effects of adipose stem cells (ASCs) derived from breast of healthy women …

[HTML][HTML] Cancer-associated adipocytes: emerging supporters in breast cancer

C Zhao, M Wu, N Zeng, M Xiong, W Hu, W Lv… - Journal of Experimental …, 2020 - Springer
Breast cancer (BC) is a malignant breast tumor confronted with high invasion, metastasis
and recurrence rate, and adipocytes are the largest components in breast tissue. The …

[HTML][HTML] Transition into inflammatory cancer-associated adipocytes in breast cancer microenvironment requires microRNA regulatory mechanism

J Lee, BS Hong, HS Ryu, HB Lee, M Lee, IA Park… - PLoS …, 2017 - journals.plos.org
The role of adipocytes in cancer microenvironment has gained focus during the recent
years. However, the characteristics of the cancer-associated adipocytes (CAA) in human …

[HTML][HTML] Role of adipose tissue-derived cytokines in the progression of inflammatory breast cancer in patients with obesity

AS Ibrahim, M El-Shinawi, S Sabet, SA Ibrahim… - Lipids in health and …, 2022 - Springer
Background Inflammatory breast cancer (IBC) represents a deadly aggressive phenotype of
breast cancer (BC) with a unique clinicopathological presentation and low survival rate. In …

Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell-like properties through adipsin

H Goto, Y Shimono, Y Funakoshi, Y Imamura… - Oncogene, 2019 - nature.com
Tumor microenvironment plays a key role for tumor development and progression. Although
adipose tissue is a predominant component of stroma in mammary tissues and secretes …