Background: The genome association databases provide valuable clues to identify novel
targets for cancer diagnosis and therapy. Genes harboring phenotype-associated …

The collection of proteins secreted from a cell—the secretome—is of particular interest in
cancer pathophysiology due to its diagnostic potential and role in tumorigenesis. However …

Biomarkers are pivotal for cancer detection, diagnosis, prognosis and therapeutic
monitoring. However, currently available cancer biomarkers have the disadvantage of …

Introduction: Tumor-associated proteins released by cancer cells and by tumor stroma cells,
referred as 'cancer secretome', represent a valuable resource for discovery of potential …

Secretome analysis has gained popularity recently as a very well-designed proteomic
approach that is being used to study various interactions and their effects on cellular activity …

Emerging proteomic tools and mass spectrometry play pivotal roles in protein identification,
quantification and characterization, even in complex biological samples. The cancer …

Secretory proteins play an important role in the tumor microenvironment and are widely
distributed throughout tumor tissues. Tumor cells secrete a protein that mediates …

In principle, targeted therapies have optimal activity against a specific subset of tumors that
depend upon the targeted molecule or pathway for growth, survival, or metastasis …

Introduction: Cancer represents one of the major causes of human deaths. Identification of
proteins as biomarkers for early detection of cancer and therapeutic targets for cancer …

Despite major improvements on the knowledge and clinical management, cancer is still a
deadly disease. Novel biomarkers for better cancer detection, diagnosis and treatment …