Background: CJM126, 2-(4-aminophenyl) benzothiazole, is a potent inhibitor of human-
derived breast carcinoma cell lines. Previous studies have shown that CJM126 elicits …

(4-aminophenyl) benzothiazole (CJM 126) elicits potent growth inhibition in human-derived
breast carcinoma cell lines, including oestrogen receptor-positive (ER+) MCF-7 wt cells …

Objective: A single mechanistic pathway cannot explain the genesis of drug resistance in
cancer. Drug resistance in cancer is a major obstacle to successful chemotherapy. KB cells …

Acquired drug resistance is a major problem in cancer treatment. To explore the genes
involved in chemosensitivity and resistance, 10 human tumour cell lines, including parental …

Background: Drug resistance is a major problem in clinical cancer chemotherapy. Several
mechanisms of resistance have been identified, but the underlying genomic changes are …

Abstract Compounds within the 2-(4-aminophenyl) benzothiazole class represent extremely
potent and selective experimental antitumour agents. The lysylamide prodrug of 2-(4-amino …

Until recently, few molecular signatures of drug resistance identified in drug-induced
resistant cancer cell models can be translated into clinical practice. Here, we defined …

Multi-drug resistance is a well-studied phenomenon in cancer research both'in vitro'and'in
vivo'. Often times, individuals studying chemotherapeutic resistance'in vitro'compare cells …

Resistance to the broad spectrum of chemotherapeutic agents in cancer cell lines and
tumors has been called multiple drug resistance (MDR). In this study, the molecular …

Acquired drug-resistance phenotype is a key factor in the relapse of patients suffering
hematological malignancies. In order to investigate the genes involved in drug resistance, a …