Collagen-a necessary accomplice in the metastatic process

PS Nerenberg, R Salsas-Escat… - Cancer genomics & …, 2007 - cgp.iiarjournals.org
The prognosis for cancer patients with metastatic disease remains poor. For cancer to
metastasize from a primary tumor to distinct sites in the body, both the extracellular matrix …

Collagens in cancer: structural regulators and guardians of cancer progression

D De Martino, JJ Bravo-Cordero - Cancer research, 2023 - AACR
Collagen is one of the most abundant proteins in animals and a major component of the
extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of …

[HTML][HTML] The role of collagen in cancer: from bench to bedside

S Xu, H Xu, W Wang, S Li, H Li, T Li, W Zhang… - Journal of translational …, 2019 - Springer
Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

[HTML][HTML] Immune modulatory properties of collagen in cancer

AMA Rřmer, ML Thorseth, DH Madsen - Frontiers in immunology, 2021 - frontiersin.org
During tumor growth the extracellular matrix (ECM) undergoes dramatic remodeling. The
normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher …

Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis

AC Martins Cavaco, S Dâmaso, S Casimiro… - Cancer and Metastasis …, 2020 - Springer
Progression through dissemination to tumor-surrounding tissues and metastasis
development is a hallmark of cancer that requires continuous cell-to-cell interactions and …

[HTML][HTML] Collagen family as promising biomarkers and therapeutic targets in cancer

L Necula, L Matei, D Dragu, I Pitica, A Neagu… - International Journal of …, 2022 - mdpi.com
Despite advances in cancer detection and therapy, it has been estimated that the incidence
of cancers will increase, while the mortality rate will continue to remain high, a fact explained …

[HTML][HTML] Collagen remodeling along cancer progression providing a novel opportunity for cancer diagnosis and treatment

K Song, Z Yu, X Zu, G Li, Z Hu, Y Xue - International Journal of Molecular …, 2022 - mdpi.com
The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Predictive value of collagen in cancer

PM Angel, SC Zambrzycki - Advances in cancer research, 2022 - Elsevier
Cancer is a complex disease and a significant cause of mortality worldwide. Over the course
of nearly all cancer types, collagen within the tumor microenvironment influences …

Role of collagen regulators in cancer treatment: A comprehensive review

T Angre, A Kumar, AK Singh, S Thareja… - Anti-Cancer Agents in …, 2022 - ingentaconnect.com
Collagen is the most important structural protein and also the main component of the extra-
cellular matrix (ECM). It plays a role in tumor progression. Collagen can be regulated by …

[HTML][HTML] Uncovering mediators of collagen degradation in the tumor microenvironment

ML Thorseth, M Carretta, C Jensen, K Mřlgaard… - Matrix Biology Plus, 2022 - Elsevier
Increased remodeling of the extracellular matrix in malignant tumors has been shown to
correlate with tumor aggressiveness and a poor prognosis. This remodeling involves …