Collagen-a necessary accomplice in the metastatic process
PS Nerenberg, R Salsas-Escat… - Cancer genomics & …, 2007 - cgp.iiarjournals.org
The prognosis for cancer patients with metastatic disease remains poor. For cancer to
metastasize from a primary tumor to distinct sites in the body, both the extracellular matrix …
metastasize from a primary tumor to distinct sites in the body, both the extracellular matrix …
Collagens in cancer: structural regulators and guardians of cancer progression
D De Martino, JJ Bravo-Cordero - Cancer research, 2023 - AACR
Collagen is one of the most abundant proteins in animals and a major component of the
extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of …
extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of …
[HTML][HTML] The role of collagen in cancer: from bench to bedside
S Xu, H Xu, W Wang, S Li, H Li, T Li, W Zhang… - Journal of translational …, 2019 - Springer
Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …
[HTML][HTML] Immune modulatory properties of collagen in cancer
AMA Rřmer, ML Thorseth, DH Madsen - Frontiers in immunology, 2021 - frontiersin.org
During tumor growth the extracellular matrix (ECM) undergoes dramatic remodeling. The
normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher …
normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher …
Collagen biology making inroads into prognosis and treatment of cancer progression and metastasis
AC Martins Cavaco, S Dâmaso, S Casimiro… - Cancer and Metastasis …, 2020 - Springer
Progression through dissemination to tumor-surrounding tissues and metastasis
development is a hallmark of cancer that requires continuous cell-to-cell interactions and …
development is a hallmark of cancer that requires continuous cell-to-cell interactions and …
[HTML][HTML] Collagen family as promising biomarkers and therapeutic targets in cancer
Despite advances in cancer detection and therapy, it has been estimated that the incidence
of cancers will increase, while the mortality rate will continue to remain high, a fact explained …
of cancers will increase, while the mortality rate will continue to remain high, a fact explained …
[HTML][HTML] Collagen remodeling along cancer progression providing a novel opportunity for cancer diagnosis and treatment
K Song, Z Yu, X Zu, G Li, Z Hu, Y Xue - International Journal of Molecular …, 2022 - mdpi.com
The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …
main component of the ECM, are greatly remodeled alongside cancer development. More …
Predictive value of collagen in cancer
PM Angel, SC Zambrzycki - Advances in cancer research, 2022 - Elsevier
Cancer is a complex disease and a significant cause of mortality worldwide. Over the course
of nearly all cancer types, collagen within the tumor microenvironment influences …
of nearly all cancer types, collagen within the tumor microenvironment influences …
Role of collagen regulators in cancer treatment: A comprehensive review
Collagen is the most important structural protein and also the main component of the extra-
cellular matrix (ECM). It plays a role in tumor progression. Collagen can be regulated by …
cellular matrix (ECM). It plays a role in tumor progression. Collagen can be regulated by …
[HTML][HTML] Uncovering mediators of collagen degradation in the tumor microenvironment
ML Thorseth, M Carretta, C Jensen, K Mřlgaard… - Matrix Biology Plus, 2022 - Elsevier
Increased remodeling of the extracellular matrix in malignant tumors has been shown to
correlate with tumor aggressiveness and a poor prognosis. This remodeling involves …
correlate with tumor aggressiveness and a poor prognosis. This remodeling involves …