Identification of Serpin (α-1-Antitrypsin) as Serum Growth Inhibitory Factor in Murine Ehrlich Carcinoma by Proteomics

FV Donenko, RH Ziganshin… - Cancer Genomics & …, 2010 - cgp.iiarjournals.org
It is well established that serum factors play a role in relapse of tumor diseases after removal
of the primary tumor. The molecular nature of these factors and their mechanism of action …

[HTML][HTML] Conformational changes in inter‑α‑trypsin inhibitor heavy chain 4 activate its tumor‑specific activity in mice with B16 melanoma

NG Kormosh, TV Davidova… - Molecular …, 2015 - spandidos-publications.com
It is known that blood serum proteins of tumor‑bearing mice display tumor‑specific activity.
However, to date, the nature of this activity has remained elusive, and no tumor‑specific …

Tumor–host interactions contribute to the elevated expression level of α1-antichymotrypsin in metastatic breast tumor xenografts

V Montel, K Pestonjamasp, E Mose, D Tarin - Differentiation, 2005 - Elsevier
We investigated α1-antichymotrypsin (ACT) gene expression in xenograft tumors generated
by two isogenic human breast cancer cell lines derived from the same parent, MDA-MB-435 …

Changes in the Serum Protein Composition in Mice with Transplanted Ehrlich's Carcinoma

NG Kormosh, RK Ziganshin, VO Shender… - Bulletin of Experimental …, 2015 - Springer
Injection of blood serum from mice with Ehrlich's carcinoma stimulates the growth of
transplanted tumor, which proves the presence of tumor-specific factors in the serum …

Potential of protein-based anti-metastatic therapy with serpins and inter α-trypsin inhibitors

UH Weidle, F Birzele… - Cancer Genomics & …, 2018 - cgp.iiarjournals.org
In this review we summarize the principles of anti-metastatic therapy with selected serpin
family proteins, such as pigment epithelial-derived factor (PEDF) and maspin, as well as …

Identification and quantification of proteins differentially secreted by a pair of normal and malignant breast‐cancer cell lines

X Liang, J Huuskonen, M Hajivandi, R Manzanedo… - …, 2009 - Wiley Online Library
Secreted proteins play a pivotal role in cellular functions. To better understand malignant
behavior, we adapted stable isotopic labeling with amino acids in cell culture technology to …

Nuclear α1-antichymotrypsin promotes chromatin condensation and inhibits proliferation of human hepatocellular carcinoma cells

M Santamaria, A Pardo–Saganta, L Alvarez–Asiain… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: α1-Antichymotrypsin (α1-ACT), a member of the serpin family
(SERPINA3), is an acute-phase protein secreted by hepatocytes in response to cytokines …

Characterization of novel squamous cell carcinoma antigen-related molecules in mice

Y Sakata, K Arima, K Takeshita, T Takai, S Aoki… - Biochemical and …, 2004 - Elsevier
The squamous cell carcinoma antigen 1 (SCCA1) and SCCA2 are unique serpins that can
inhibit cysteine proteinases. SQN-5, their mouse ortholog, has already been identified, and …

[CITATION][C] Alpha 1 antichymotrypsin is aberrantly expressed during melanoma progression and predicts poor survival for patients with metastatic melanoma

Y Wang, H Jiang, D Dai, M Su… - Pigment cell & …, 2010 - Wiley Online Library
Dear Sir, Prediction of long term survival outcomes for melanoma patients is not only critical
clinically for patient management but also highly valuable for patient risk stratification in …

[HTML][HTML] The role of selected serpins in gastrointestinal (GI) malignancies

S Pączek, B Mroczko - Journal of Clinical Medicine, 2022 - mdpi.com
Gastrointestinal (GI) cancers, which are a diverse group of malignant diseases, represent a
major healthcare problem around the world. Due to the lack of specific symptoms in the early …