Background: Circulating mRNA is a less invasive and more easily accessed source of
samples for biomedical research and clinical applications. However, it is of poor quality. We …

Circulating microRNAs (miRNAs) are considered as reliable candidates for biomarker
discovery. RNA-Sequencing has become the most suitable technique to accurately quantify …

The human circulation contains cell-free DNA and non-coding microRNA (miRNA). Less is
known about the presence of messenger RNA (mRNA). This report profiles the human …

Lung cancer (LC) remains associated with significant mortality worldwide. The lack of
reliable noninvasive biomarkers and targeted therapies contributes to poor survival rate …

Lung cancer accounts for more than half of the new cancers diagnosed world-wide with poor
survival rates. Despite the development of chemical, radiological, and immunotherapies …

Background Circulating microRNAs (ct-miRs) are promising cancer biomarkers. This study
focuses on platform comparison to assess performance variability, agreement in the …

Gene expression analysis has become routine, thanks to microarrays and now RNA
sequencing, which is helping researchers discover novel RNA forms and variants. New …

For cancers and other pathologies, early diagnosis remains the most promising path to
survival. Profiling of longitudinal cohorts facilitates insights into trajectories of biomarkers …

Background Lung cancer is one of the most common malignancies, and it has extremely
high incidence and mortality rates. Although there have been many studies focused on lung …

The gold standard for cancer diagnosis remains the histological examination of affected
tissue, obtained either by surgical excision, or radiologically guided biopsy. Such …