The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

Research into fundamental principles and the testing of therapeutic hypotheses for treatment
of human disease is commonly performed on mouse models of human diseases. Although …

Although cancer-associated fibroblasts (CAFs) are viewed as a promising therapeutic target,
the design of rational therapy has been hampered by two key obstacles. First, attempts to …

Human osteopontin is subject to alternative splicing, which generates three isoforms, termed
OPNa, OPNb and OPNc. These variants show specific expression and roles in different cell …

RNA splicing, the enzymatic process of removing segments of premature RNA to produce
mature RNA, is a key mediator of proteome diversity and regulator of gene expression …

Alterations in the abundance or activities of alternative splicing regulators generate
alternatively spliced variants that contribute to multiple aspects of tumor establishment …

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with
insufficient options for therapy. In order to identify new targets and treatment modalities we …

In the pathogenesis of autoimmune disorders, the modulation of leukocytes′ trafficking
plays a central role, still poorly understood. Here, we focused on the effect of TLR2 ligands …

Previous studies have shown that CD44 containing variant exon v6 (CD44v6) is highly
expressed in many cancers and is related to tumor metastasis. However, the detailed …

Alternative splicing controls gene expression at the transcriptional level, producing
structurally and functionally distinct protein heterodimers. Aberrant alternative splicing …