Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy

GV Sherbet - Cancer letters, 2009 - Elsevier
The growth, invasion and metastatic spread of cancer have been identified with the
deregulation of cell proliferation, altered intercellular and cell-substratum adhesion and …

[HTML][HTML] Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells

Y Lei, K Huang, C Gao, QC Lau, H Pan, K Xie… - Molecular & Cellular …, 2011 - ASBMB
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and second
in females worldwide. Unfortunately 40–50% of patients already have metastatic disease at …

Proteomics-based strategies to identify proteins relevant to chronic lymphocytic leukemia

SA Alsagaby, S Khanna, KW Hart, G Pratt… - Journal of proteome …, 2014 - ACS Publications
Chronic lymphocytic leukemia (CLL), a malignant B-cell disorder, is characterized by a
heterogeneous clinical course. Two-dimensional nano liquid chromatography (2D-nano …

[HTML][HTML] Inferring evolutionary trajectories from cross-sectional transcriptomic data to mirror lung adenocarcinoma progression

K Huang, Y Zhang, H Gong, Z Qiao… - PLOS Computational …, 2023 - journals.plos.org
Lung adenocarcinoma (LUAD) is a deadly tumor with dynamic evolutionary process.
Although much endeavors have been made in identifying the temporal patterns of cancer …

[HTML][HTML] Overexpression of Stathmin 1 correlates with poor prognosis and promotes cell migration and proliferation in oesophageal squamous cell carcinoma

PZ Ni, JZ He, ZY Wu, X Ji, LQ Chen… - Oncology …, 2017 - spandidos-publications.com
Abstract Stathmin 1 (STMN1) is a microtubule-regulated protein that plays an important role
in tumour cell proliferation and migration. Overexpression of STMN1 is associated with …

Anti-STMN1 therapy improves sensitivity to antimicrotubule drugs in esophageal squamous cell carcinoma

S Wang, J Akhtar, Z Wang - Tumor Biology, 2015 - Springer
Stathmin (STMN1) regulates microtubule dynamics by promoting depolymerization of
microtubules and/or preventing polymerization of tubulin heterodimers. Several studies have …

[HTML][HTML] Lentiviral-mediated RNA interference targeting stathmin1 gene in human gastric cancer cells inhibits proliferation in vitro and tumor growth in vivo

J Akhtar, Z Wang, ZP Zhang, MM Bi - Journal of translational medicine, 2013 - Springer
Background Gastric cancer is highly aggressive disease. Despite advances in diagnosis
and therapy, the prognosis is still poor. Various genetic and molecular alterations are found …

[HTML][HTML] Sequenced combinations of cisplatin and selected phytochemicals towards overcoming drug resistance in ovarian tumour models

SI Althurwi, JQ Yu, P Beale, F Huq - International journal of molecular …, 2020 - mdpi.com
In the present study, cisplatin, artemisinin, and oleanolic acid were evaluated alone, and in
combination, on human ovarian A2780, A2780ZD0473R, and A2780cisR cancer cell lines …

[HTML][HTML] Down-regulation of stathmin is required for the phenotypic changes and classical activation of macrophages

K Xu, RE Harrison - Journal of Biological Chemistry, 2015 - ASBMB
Macrophages are important cells of innate immunity with specialized capacity for recognition
and elimination of pathogens and presentation of antigens to lymphocytes for adaptive …

Effectiveness of local injection of lentivirus‐delivered stathmin1 and stathmin1 shRNA in human gastric cancer xenograft mouse

J Akhtar, Z Wang, C Yu… - … of Gastroenterology and …, 2014 - Wiley Online Library
Abstract Background and Aim We have reported previously that RNA interference targeting
stathmin1 (STMN1) gene in human gastric cancer cells inhibits proliferation in vitro and …