[PDF][PDF] Gains of 20q11. 21 in human pluripotent stem cells: Insights from cancer research
N Krivec, MS Ghosh, C Spits - Stem Cell Reports, 2023 - cell.com
The genetic abnormalities observed in hPSC cultures worldwide have been suggested to
pose an important hurdle in their safe use in regenerative medicine due to the possibility of …
pose an important hurdle in their safe use in regenerative medicine due to the possibility of …
[HTML][HTML] Co-Occurrence of Beckwith–Wiedemann Syndrome and Early-Onset Colorectal Cancer
F Cecere, L Pignata, B Hay Mele, A Saadat… - Cancers, 2023 - mdpi.com
Simple Summary Beckwith–Wiedemann Spectrum (BWSp) is a disorder predisposing to
tumors of embryonic origin arising during childhood. Little is known concerning tumor risk …
tumors of embryonic origin arising during childhood. Little is known concerning tumor risk …
Oncogenic miR‐1825 promotes head and neck carcinogenesis via targeting FREM1
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant
cancer type worldwide. Although the therapeutic modalities currently used for patients with …
cancer type worldwide. Although the therapeutic modalities currently used for patients with …
[HTML][HTML] Measuring cancer driving force of chromosomal aberrations through multi-layer Boolean implication networks
Multi-layer Complex networks are commonly used for modeling and analysing biological
entities. This paper presents the advantage of using COMBO (Combining Multi Bio Omics) to …
entities. This paper presents the advantage of using COMBO (Combining Multi Bio Omics) to …
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies
Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to
the presence of drug resistant clonal lineages. However, identifying the characteristics of …
the presence of drug resistant clonal lineages. However, identifying the characteristics of …
Combo: A computational framework to analyze rna-seq and methylation data through heterogeneous multi-layer networks
Multi-layer Complex networks are commonly used for modeling and analysing biological
entities. This paper presents a new computational framework called COMBO (Combining …
entities. This paper presents a new computational framework called COMBO (Combining …
Characterization of copy number alterations in Pakistani patients with colorectal cancer
CT Marcinak, BR McDonald, H Zubairi, S Siddique… - medRxiv, 2023 - medrxiv.org
Introduction: Incidence and mortality rates of colorectal cancer (CRC) in South Asia are
expected to rise by 70% between 2020 and 2040. Despite recent advances in the …
expected to rise by 70% between 2020 and 2040. Despite recent advances in the …
[HTML][HTML] Cell models for chromosome 20q11. 21 amplification and drug sensitivities in colorectal cancer
IA Voutsadakis - Medicina, 2021 - mdpi.com
Background and objectives: The chromosome locus 20q11. 21 is a commonly amplified
locus in colorectal cancer, with a prevalence of 8% to 9%. Several candidate cancer …
locus in colorectal cancer, with a prevalence of 8% to 9%. Several candidate cancer …
Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
N Krivec, E Couvreu de Deckersberg, Y Lei… - bioRxiv, 2023 - biorxiv.org
Gains of 1q are a highly recurrent chromosomal abnormality in human pluripotent stem cells.
In this work, we show that gains of 1q impact the differentiation capacity to derivates of the …
In this work, we show that gains of 1q impact the differentiation capacity to derivates of the …
Safety Issues Related to Pluripotent Stem Cell-Based Therapies: Tumour Risk
S Hillenius, J Montilla-Rojo, TF Eleveld… - Pluripotent Stem Cell …, 2024 - Springer
As the exciting era of regenerative medicine has dawned, considerable efforts aim to further
develop human pluripotent stem cell (hPSC)-based therapies for a plethora of diseases …
develop human pluripotent stem cell (hPSC)-based therapies for a plethora of diseases …