[HTML][HTML] IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies

J Bennett, DT Starczynowski - Current Opinion in Hematology, 2022 - journals.lww.com
IRAK-targeted therapies that have matriculated to early phase trials are yielding promising
preliminary results. However, studies of IRAK kinase signaling continue to defy conventional …

[HTML][HTML] MicroRNAs and the diagnosis of childhood acute lymphoblastic leukemia: systematic review, meta-analysis and Re-analysis with novel small RNA-seq tools

I Kyriakidis, K Kyriakidis, A Tsezou - Cancers, 2022 - mdpi.com
Simple Summary MicroRNAs (miRNAs) have been under the spotlight for the last three
decades. These non-coding RNAs seem to be dynamic regulators of mRNA stability and …

[HTML][HTML] Impact of Mir196a-2 genotypes on colorectal cancer risk in Taiwan

TC Yueh, YC Wang, YT Chin, YC Hung… - International journal of …, 2023 - mdpi.com
We aimed to investigate the association between genotypes for mir146a and mir196a-2 and
the risk of developing colorectal cancer (CRC). We used polymerase chain reaction …

Novel contribution of long non-coding RNA MEG3 genotype to prediction of childhood leukemia risk

JS Pei, WS Chang, CC Chen, MC Mong… - Cancer Genomics & …, 2022 - cgp.iiarjournals.org
Background/Aim: Acute lymphoblastic leukemia (ALL) is frequent among children. Few
studies have researched the relationship between maternally expressed gene 3 (MEG3) …

Significant association of cyclin D1 promoter genotypes with asthma susceptibility in Taiwan

CH Li, KL Chiu, TC Hsia, TC Shen, LH Chen, CC Yu… - in vivo, 2021 - iv.iiarjournals.org
Background/Aim: The molecular mechanisms underlying the association between cell cycle
and asthma are poorly understood, and cyclin D1 (CCND1) is found to be upregulated in …

[HTML][HTML] Significant associations of lncRNA H19 genotypes with susceptibility to childhood leukemia in Taiwan

JS Pei, CC Chen, WS Chang, YC Wang, JC Chen… - Pharmaceuticals, 2021 - mdpi.com
The purpose of our study was to investigate whether genetic variations in lncRNA H19 were
associated with susceptibility to childhood leukemia. Two hundred and sixty-six childhood …

MiR-196a-2 genotypes determine the susceptibility and early onset of childhood acute lymphoblastic leukemia

CC Chen, PC Hsu, LC Shih, YN Hsu, CC Kuo… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: The roles of microRNAs (miRNAs) in tumorigenesis have attracted a lot of
attention. The current study aimed at examining the association of the miR-196a-2 …

Contribution of cyclin-dependent kinase inhibitor 1B genotypes to childhood leukemia risk

JS Pei, WS Chang, PC Hsu, CC Chen, YC Yang… - in vivo, 2022 - iv.iiarjournals.org
Background/Aim: Although genetic differences in cell-cycle control genes have been
associated with cancer risk, to our knowledge, no report has specifically examined the role …

[HTML][HTML] Association between the mir-146a rs2910164 polymorphism and childhood acute lymphoblastic leukemia susceptibility in an asian population

D Zou, J Yin, Z Ye, Q Zeng, Y Wang - Frontiers in genetics, 2020 - frontiersin.org
Background: miR-146a has been demonstrated to be involved in normal hematopoiesis and
the pathogenesis of many hematological malignancies by inhibiting the expression of its …

Significant contribution of interleukin-18 genotypes to childhood acute lymphocytic leukemia risk in Taiwanese

CC Chen, HE Tzeng, CC Kuo, SNS Lim… - Anticancer …, 2022 - ar.iiarjournals.org
Abstract Background/Aim: Evidence has shown that interleukin-18 (IL-18) has both antitumor
and pro-tumor effects in various types of leukemia. The current study aimed at investigating …