Molecular classification and future therapeutic challenges of triple-negative breast cancer

N Garmpis, C Damaskos, A Garmpi, K Nikolettos… - in vivo, 2020 - iv.iiarjournals.org
Triple-negative breast cancer (TNBC) is an extremely diverse group of breast tumors, with
aggressive clinical behavior, higher rates of distant recurrence and worse overall survival …

The cell cycle‐related genes RHAMM, AURKA, TPX2, PLK1, and PLK4 are associated with the poor prognosis of breast cancer patients

I Kahl, J Mense, C Finke, AL Boller… - Journal of Cellular …, 2022 - Wiley Online Library
Breast cancer is the third most common type of cancer diagnosed. Cell cycle is a complex
but highly organized and controlled process, in which normal cells sense mitogenic growth …

[HTML][HTML] Obesity promotes radioresistance through SERPINE1-mediated aggressiveness and DNA repair of triple-negative breast cancer

YH Su, YZ Wu, DK Ann, JLY Chen, CY Kuo - Cell Death & Disease, 2023 - nature.com
Obesity is a risk factor in various types of cancer, including breast cancer. The disturbance of
adipose tissue in obesity highly correlates with cancer progression and resistance to …

[HTML][HTML] Molecular investigation on a triple negative breast cancer xenograft model exposed to proton beams

FP Cammarata, GI Forte, G Broggi, V Bravatà… - International Journal of …, 2020 - mdpi.com
Specific breast cancer (BC) subtypes are associated with bad prognoses due to the absence
of successful treatment plans. The triple-negative breast cancer (TNBC) subtype, with …

[HTML][HTML] Biological and mechanical characterization of the random positioning machine (rpm) for microgravity simulations

M Calvaruso, C Militello, L Minafra, V La Regina… - Life, 2021 - mdpi.com
The rapid improvement of space technologies is leading to the continuous increase of space
missions that will soon bring humans back to the Moon and, in the coming future, toward …

[HTML][HTML] Activated ERK signaling is one of the major hub signals related to the acquisition of radiotherapy-resistant MDA-MB-231 breast cancer cells

A Paramanantham, EJ Jung, SIL Go, BK Jeong… - International Journal of …, 2021 - mdpi.com
Breast cancer is one of the major causes of deaths due to cancer, especially in women. The
crucial barrier for breast cancer treatment is resistance to radiation therapy, one of the …

[HTML][HTML] Transcriptomics and metabolomics integration reveals redox-dependent metabolic rewiring in breast cancer cells

M Bonanomi, N Salmistraro, G Fiscon, F Conte, P Paci… - Cancers, 2021 - mdpi.com
Simple Summary Metabolic rewiring fuels cancer proliferation by enhanced glycolysis and
the increased NADH/NAD+ ratio. In this study, we highlight the critical role of NADH in the …

[HTML][HTML] Hypoxia transcriptomic modifications induced by proton irradiation in u87 glioblastoma multiforme cell line

V Bravatà, W Tinganelli, FP Cammarata… - Journal of Personalized …, 2021 - mdpi.com
In Glioblastoma Multiforme (GBM), hypoxia is associated with radioresistance and poor
prognosis. Since standard GBM treatments are not always effective, new strategies are …

[PDF][PDF] Txnrd1 as a prognosticator for recurrence, metastasis and response to neoadjuvant chemotherapy and radiotherapy in breast cancer patients

RS Patwardhan, A Rai, D Sharma, SK Sandur… - Heliyon, 2024 - cell.com
Abstract Thioredoxin reductase 1 (Txnrd1) is known to have prognostic significance in a
subset of breast cancer patients. Despite the pivotal role of Txnrd1 in regulating several …

Impact on the Transcriptome of Proton Beam Irradiation Targeted at Healthy Cardiac Tissue of Mice

C Sala, M Tarozzi, G Simonetti, M Pazzaglia… - Cancers, 2024 - mdpi.com
Proton beam therapy is considered a step forward with respect to electromagnetic radiation,
thanks to the reduction in the dose delivered. Among unwanted effects to healthy tissue …