[HTML][HTML] Improving immunotherapy efficacy in soft-tissue sarcomas: A biomarker driven and histotype tailored review
M Roulleaux Dugage, EF Nassif, A Italiano… - Frontiers in …, 2021 - frontiersin.org
Anti-PD-(L) 1 therapies yield a disappointing response rate of 15% across soft-tissue
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …
ABL1-directed inhibitors for CML: efficacy, resistance and future perspectives
M Massimino, S Stella, E Tirro, MS Pennisi… - Anticancer …, 2020 - ar.iiarjournals.org
The introduction of tyrosine kinase inhibitors (TKIs) directed against the catalytic activity of
the ABL tyrosine kinase has considerably improved the outcome of chronic myeloid …
the ABL tyrosine kinase has considerably improved the outcome of chronic myeloid …
[HTML][HTML] Targeting glutamine metabolism slows soft tissue sarcoma growth
Tumour cells frequently utilize glutamine to meet bioenergetic and biosynthetic demands of
rapid cell growth. However, glutamine dependence can be highly variable between in vitro …
rapid cell growth. However, glutamine dependence can be highly variable between in vitro …
[HTML][HTML] Undifferentiated pleomorphic sarcoma
A Robles-Tenorio, G Solis-Ledesma - 2021 - europepmc.org
Objectives: Review the etiology of undifferentiated pleomorphic sarcoma. Describe the
evaluation protocol for undifferentiated pleomorphic sarcoma. Outline treatment alternatives …
evaluation protocol for undifferentiated pleomorphic sarcoma. Outline treatment alternatives …
[HTML][HTML] Comprehensive genomic profile of cholangiocarcinomas in China
W Tian, W Hu, X Shi, P Liu, X Ma… - Oncology …, 2020 - spandidos-publications.com
Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as locally
advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in …
advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in …
[HTML][HTML] Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models
WR Gutierrez, A Scherer, GR McGivney… - Scientific reports, 2021 - nature.com
Immune cells play critical functions in cancer, and mice with intact immune systems are vital
to understanding tumor immunology. Both genetically engineered mouse models (GEMMs) …
to understanding tumor immunology. Both genetically engineered mouse models (GEMMs) …
[HTML][HTML] Potential application of genomic profiling for the diagnosis and treatment of patients with sarcoma
L Xu, X Xie, X Shi, P Zhang, A Liu… - Oncology …, 2021 - spandidos-publications.com
Sarcomas represent a heterogeneous group of mesenchymal malignancies arising at
various locations in the soft tissue and bone. Though a rare disease, sarcoma affects …
various locations in the soft tissue and bone. Though a rare disease, sarcoma affects …
[HTML][HTML] The sarcoma immune landscape: emerging challenges, prognostic significance and prospective impact for immunotherapy approaches
A Koumarianou, J Duran-Moreno - Cancers, 2021 - mdpi.com
Simple Summary Sarcomas are a rare disease with high rates of recurrence and poor
prognosis. Important discoveries about the biology of sarcomas have been done during the …
prognosis. Important discoveries about the biology of sarcomas have been done during the …
Targeting BCL-2 as a therapeutic strategy for primary p210BCR-ABL1-positive B-ALL cells
M Massimino, E Tirro, S Stella, MS Pennisi, SR Vitale… - in vivo, 2020 - iv.iiarjournals.org
Background/Aim: Philadelphia-positive acute lymphoblastic leukemia (Ph+ B-ALL) is caused
by the malignant transformation of lymphoid cells induced by BCR-ABL1 constitutive …
by the malignant transformation of lymphoid cells induced by BCR-ABL1 constitutive …
Next generation sequencing reveals pathogenic and actionable genetic alterations of soft tissue sarcoma in Chinese patients: a single center experience
G Jin, C Wang, D Jia, W Qian, C Yin… - … in Cancer Research …, 2021 - journals.sagepub.com
Background: Next generation sequencing (NGS) has systematically investigated the
genomic landscape of soft tissue sarcoma (STS) in Western patients, but few reports have …
genomic landscape of soft tissue sarcoma (STS) in Western patients, but few reports have …