Anti-PD-(L) 1 therapies yield a disappointing response rate of 15% across soft-tissue
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …

The introduction of tyrosine kinase inhibitors (TKIs) directed against the catalytic activity of
the ABL tyrosine kinase has considerably improved the outcome of chronic myeloid …

Tumour cells frequently utilize glutamine to meet bioenergetic and biosynthetic demands of
rapid cell growth. However, glutamine dependence can be highly variable between in vitro …

Objectives: Review the etiology of undifferentiated pleomorphic sarcoma. Describe the
evaluation protocol for undifferentiated pleomorphic sarcoma. Outline treatment alternatives …

Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as locally
advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in …

Immune cells play critical functions in cancer, and mice with intact immune systems are vital
to understanding tumor immunology. Both genetically engineered mouse models (GEMMs) …

Sarcomas represent a heterogeneous group of mesenchymal malignancies arising at
various locations in the soft tissue and bone. Though a rare disease, sarcoma affects …

Simple Summary Sarcomas are a rare disease with high rates of recurrence and poor
prognosis. Important discoveries about the biology of sarcomas have been done during the …

Background/Aim: Philadelphia-positive acute lymphoblastic leukemia (Ph+ B-ALL) is caused
by the malignant transformation of lymphoid cells induced by BCR-ABL1 constitutive …

Background: Next generation sequencing (NGS) has systematically investigated the
genomic landscape of soft tissue sarcoma (STS) in Western patients, but few reports have …