[HTML][HTML] Revelation of proteomic indicators for colorectal cancer in initial stages of development

AT Kopylov, AA Stepanov, KA Malsagova, D Soni… - Molecules, 2020 - mdpi.com
Background: Colorectal cancer (CRC) at a current clinical level is still hardly diagnosed,
especially with regard to nascent tumors, which are typically asymptotic. Searching for …

An Overview on the Emerging Role of the Plasma Protease Inhibitor Protein ITIH5 as a Metastasis Suppressor

K Subramaniyam, S Harihar - Cell Biochemistry and Biophysics, 2024 - Springer
Most cancers are not detected until they have progressed to the point of becoming malignant
and life-threatening. Chemotherapy and conventional medicines are often ineffective …

Understanding collagen interactions and their targeted regulation by novel drugs

M Gallorini, S Carradori - Expert Opinion on Drug Discovery, 2021 - Taylor & Francis
Introduction: Among protein and fibers in the extracellular matrix (ECM), collagen is the most
copious and widely employed in cosmetic, food, pharmaceutical, and biomedical industries …

[HTML][HTML] Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny-complement components C3 and C4 are post …

B Magnadóttir, BT Bragason, IR Bricknell… - Developmental & …, 2019 - Elsevier
Post-translational protein deimination is mediated by peptidylarginine deiminases (PADs),
which are calcium dependent enzymes conserved throughout phylogeny with physiological …

Proteomic profiling of cutaneous melanoma explains the aggressiveness of distant organ metastasis

A Azimi, E Patrick, R Teh, J Kim… - Experimental …, 2023 - Wiley Online Library
Despite recent developments in managing metastatic melanomas, patients' overall survival
remains low. Therefore, the current study aims to understand better the proteome‐wide …

[HTML][HTML] Quantitative proteomic analysis of GnRH agonist treated GBM cell line LN229 revealed regulatory proteins inhibiting cancer cell proliferation

PH Tripathi, J Akhtar, J Arora, RK Saran, N Mishra… - BMC cancer, 2022 - Springer
Abstract Background Gonadotropin-releasing hormone (GnRH) receptor, a rhodopsin-like G-
protein coupled receptor (GPCR) family member involved in GnRH signaling, is reported to …

Deiminated proteins in extracellular vesicles and serum of llama (Lama glama)—Novel insights into camelid immunity

MF Criscitiello, I Kraev, S Lange - Molecular immunology, 2020 - Elsevier
Peptidylarginine deiminases (PADs) are phylogenetically conserved calcium-dependent
enzymes which post-translationally convert arginine into citrulline in target proteins in an …

[HTML][HTML] Alpha1-antitrypsin protects lung cancer cells from staurosporine-induced apoptosis: the role of bacterial lipopolysaccharide

N Schwarz, S Tumpara, S Wrenger, E Ercetin… - Scientific Reports, 2020 - nature.com
Elevated levels of plasma alpha1-antitrypsin (AAT) correlate with a poor prognosis of
various cancers. Herein, we investigated effects of exogenous AAT on non-small lung …

[HTML][HTML] Maspin, syndecan-1, and Ki-67 in the odontogenic keratocyst: An immunohistochemical analysis

HM Hammad, OM Nagrash, RA Safadi - International Journal of …, 2020 - hindawi.com
The odontogenic keratocyst (OKC) is a controversial lesion that was reclassified as a tumor
with the name “keratocystic odontogenic tumor” in 2005. The reclassification was revoked …

[HTML][HTML] ITIH5-derived polypeptides covering the VIT domain suppress the growth of human cancer cells in vitro

M Rose, S Huth, M Wiesehöfer, J Ehling, C Henkel… - Cancers, 2022 - mdpi.com
Simple Summary ITIH5 has been shown to be an effective tumor and metastasis suppressor
which is being lost in various tumor entities including breast, bladder and lung cancer. In the …