[HTML][HTML] Chemical complementarity between immune receptors and cancer mutants, independent of antigen presentation protein binding, is associated with increased …
M Hsiang, BI Chobrutskiy, M Diaz, TI Huda… - Translational …, 2021 - Elsevier
Uterine cancer has been associated with a T-cell immune response that leads to increased
survival. Therefore, we used several bioinformatics approaches to explore specific …
survival. Therefore, we used several bioinformatics approaches to explore specific …
Matrix‐Metalloprotease Resistant Mucin‐16 (MUC16) Peptide Mutants Represent a Worse Lung Adenocarcinoma Outcome
JS Patel, BM Callahan, BI Chobrutskiy… - PROTEOMICS …, 2019 - Wiley Online Library
Purpose The relationship of lung adenocarcinoma (LUAD)–specific proteases and the
mutant profile of cytoskeletal and extracellular matrix proteins (CECMPs) are examined …
mutant profile of cytoskeletal and extracellular matrix proteins (CECMPs) are examined …
Cytoskeleton and ECM tumor mutant peptides: Increased protease sensitivities and potential consequences for the HLA class I mutant epitope reservoir
BM Callahan, JS Patel, TJ Fawcett… - International Journal of …, 2018 - Wiley Online Library
Cytoskeleton and extracellular matrix‐related proteins (CECMPs) represent the most
common class of cancer mutants, owing to the large size of their coding regions and the …
common class of cancer mutants, owing to the large size of their coding regions and the …
Smoking correlates with increased cytoskeletal protein‐related coding region mutations in the lung and head and neck datasets of the cancer genome atlas
JM Yavorski, G Blanck - Physiological Reports, 2016 - Wiley Online Library
Cancer from smoking tobacco is considered dependent on mutagens, but significant
molecular aspects of smoking‐specific, cancer development remain unknown. We defined …
molecular aspects of smoking‐specific, cancer development remain unknown. We defined …
Mutant cytoskeletal and ECM peptides sensitive to the ST14 protease are associated with a worse outcome for glioblastoma multiforme
S Zaman, BI Chobrutskiy, JS Patel, BM Callahan… - Biochemical and …, 2018 - Elsevier
We previously identified a set of the most frequently mutated cytoskeleton-and extracellular
matrix-related proteins (CECMPs) in numerous cancer datasets. In this report, we used a …
matrix-related proteins (CECMPs) in numerous cancer datasets. In this report, we used a …
TCGA: Increased oncoprotein coding region mutations correlate with a greater expression of apoptosis-effector genes and a positive outcome for stomach …
JM Yavorski, G Blanck - Cell cycle, 2016 - Taylor & Francis
Oncogene mutations are primarily thought to facilitate uncontrolled cell growth. However,
overexpression of oncoproteins likely leads to apoptosis in a feed forward mechanism …
overexpression of oncoproteins likely leads to apoptosis in a feed forward mechanism …
Characterization of prognostic factors and the efficacy of adjuvant s-1 chemotherapy in patients with post-surgery extrahepatic bile duct cancer
T Okabayashi, Y Shima, J Iwata, S Morita… - Anticancer …, 2017 - ar.iiarjournals.org
Background/Aim: There is no clear consensus on the type of adjuvant therapy that should be
used for patients with extrahepatic bile duct cancer. Patients and Methods: Two hundred and …
used for patients with extrahepatic bile duct cancer. Patients and Methods: Two hundred and …
[HTML][HTML] Protected cytoskeletal‑related proteins: Towards a resolution of contradictions regarding the role of the cytoskeleton in cancer
DT Segarra, JM Yavorski… - Biomedical …, 2017 - spandidos-publications.com
Initial reports of the role of the cytoskeleton in cancer indicated that tumor cells with a more
disorganized cytoskeleton were more tumorigenic. These reports were based on stains for …
disorganized cytoskeleton were more tumorigenic. These reports were based on stains for …
Identification of sets of cytoskeletal related and adhesion-related coding region mutations in the TCGA melanoma dataset that correlate with a negative outcome
JM Yavorski, RJ Stoll, MD Samy, JA Mauro… - Current …, 2017 - ingentaconnect.com
Background: Relatively little cancer genome atlas data has been associated with clinically
relevant stratifications of individual cancers. Results: Mutations in two subsets of a …
relevant stratifications of individual cancers. Results: Mutations in two subsets of a …
[HTML][HTML] The human, F-actin-based cytoskeleton as a mutagen sensor
NM Clark, CA Garcia Galindo, VK Patel, ML Parry… - Cancer Cell …, 2017 - Springer
Background Forty years ago the actin cytoskeleton was determined to be disrupted in
fibroblasts from persons with DNA repair-defective, hereditary colon cancer, with no clear …
fibroblasts from persons with DNA repair-defective, hereditary colon cancer, with no clear …