S100 proteins in cancer

AR Bresnick, DJ Weber, DB Zimmer - Nature Reviews Cancer, 2015 - nature.com
In humans, the S100 protein family is composed of 21 members that exhibit a high degree of
structural similarity, but are not functionally interchangeable. This family of proteins …

[HTML][HTML] New angiogenic regulators produced by TAMs: perspective for targeting tumor angiogenesis

I Larionova, E Kazakova, T Gerashchenko… - Cancers, 2021 - mdpi.com
Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

Significance of p53 overexpression in the prediction of the malignant transformation risk of oral potentially malignant disorders: A systematic review and meta-analysis

P Ramos-Garcia, MA Gonzalez-Moles… - Oral oncology, 2022 - Elsevier
Objectives To evaluate the current evidence in relation to the predictive value of p53
overexpression as a biomarker of the malignant transformation risk in oral potentially …

The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma

T Fukusumi, JA Califano - Journal of dental research, 2018 - journals.sagepub.com
Comprehensive genomic analyses have been performed for head and neck squamous cell
carcinoma (HNSCC), revealing a significant rate of NOTCH1 mutations and identifying …

“Omics” in oral cancer: New approaches for biomarker discovery

V Rai, R Mukherjee, AK Ghosh, A Routray… - Archives of Oral …, 2018 - Elsevier
Objectives In this review paper, we explored the application of “omics” approaches in the
study of oral cancer (OC). It will provide a better understanding of how “omics” approaches …

Targeting Notch4 in cancer: molecular mechanisms and therapeutic perspectives

M Xiu, X Zeng, R Shan, W Wen, J Li… - Cancer Management and …, 2021 - Taylor & Francis
The dysregulation of Notch signaling is found in many cancers and is closely related to
cancer progression. As an important Notch receptor, abnormal Notch4 expression affects …

Calcium role in human carcinogenesis: a comprehensive analysis and critical review of literature

B Kadio, S Yaya, A Basak, K Djè, J Gomes… - Cancer and Metastasis …, 2016 - Springer
The central role played by calcium ion in biological systems has generated an interest for its
potential implication in human malignancies. Thus, lines of research, on possible …

[HTML][HTML] S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma

D Sapkota, O Bruland, H Parajuli, TA Osman, MT Teh… - BMC cancer, 2015 - Springer
Background Altered expression of S100A16 has been reported in human cancers, but its
biological role in tumorigenesis is not fully understood. This study aimed to investigate the …

[HTML][HTML] miR-203 inhibits arecoline-induced epithelial‑mesenchymal transition by regulating secreted frizzled-related protein 4 and transmembrane-4 L six family …

L Zheng, X Jian, F Guo, N Li, C Jiang… - Oncology …, 2015 - spandidos-publications.com
Oral submucous fibrosis (OSF) is a potentially malignant disease predominantly found in
Asian people. The areca nut has been implicated in this disease. Arecoline, one of the areca …

Signature of genetic associations in oral cancer

V Sharma, A Nandan, AK Sharma, H Singh… - Tumor …, 2017 - journals.sagepub.com
Oral cancer etiology is complex and controlled by multi-factorial events including genetic
events. Candidate gene studies, genome-wide association studies, and next-generation …