Medicinal plants and phytochemicals against multidrug-resistant tumor cells expressing ABCB1, ABCG2, or ABCB5: a synopsis of 2 decades
Multidrug resistance is a major factor causing the failure of cancer chemotherapy. Efflux
pumps of the ATP-binding cassette (ABC) transporter family expel a large array of diverse …
pumps of the ATP-binding cassette (ABC) transporter family expel a large array of diverse …
Pharmacogenomics of a traditional Japanese herbal medicine (Kampo) for cancer therapy
T Efferth, H Miyachi, H Bartsch - Cancer genomics & proteomics, 2007 - cgp.iiarjournals.org
In the present review, we give a short introduction into the history, philosophy and traditional
diagnosis and therapy of Kampo, which has its origins in traditional Chinese medicine. The …
diagnosis and therapy of Kampo, which has its origins in traditional Chinese medicine. The …
The effect of liposomal size on the targeted delivery of doxorubicin to Integrin αvβ3-expressing tumor endothelial cells
G Kibria, H Hatakeyama, N Ohga, K Hida, H Harashima - Biomaterials, 2013 - Elsevier
Size of the liposomes (LPs) specially governs its biodistribution. In this study, LPs were
developed with controlled sizes, where variation in LP size dictates the ligand–receptor …
developed with controlled sizes, where variation in LP size dictates the ligand–receptor …
The role of copper in drug-resistant murine and human tumors
Multidrug resistance (MDR) is still a major threat to successful clinical application of cancer
chemotherapy. Copper plays an important role in biological systems, and copper is also …
chemotherapy. Copper plays an important role in biological systems, and copper is also …
Comparative study of the sensitivities of cancer cells to doxorubicin, and relationships between the effect of the drug-efflux pump P-gp
G Kibria, H Hatakeyama, K Akiyama, K Hida… - Biological and …, 2014 - jstage.jst.go.jp
Multi-drug resistance (MDR) of cancers to chemotherapy including doxorubicin (DOX) is
mediated by several factors. To design an effective therapy for the treatment of …
mediated by several factors. To design an effective therapy for the treatment of …
Inhibition of P-glycoprotein at the blood–brain barrier by phytochemicals derived from traditional Chinese medicine
A Mahringer, S Karamustafa, D Klotz… - Cancer Genomics & …, 2010 - cgp.iiarjournals.org
The blood–brain barrier (BBB) is a key determinant for drug transport through brain vessels.
It restricts the pharmacological efficacy in numerous neurological diseases, including brain …
It restricts the pharmacological efficacy in numerous neurological diseases, including brain …
Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals
Epidermal growth factor receptors (EGFR, HER2, HER3) activate signal transduction
pathways involved in cancer proliferation, apoptosis, differentiation, metastasis, and …
pathways involved in cancer proliferation, apoptosis, differentiation, metastasis, and …
Role of transporter genes in cisplatin resistance
VB Konkimalla, B Kaina, T Efferth - In Vivo, 2008 - iv.iiarjournals.org
The 50% inhibitory concentration (IC50) values for cisplatin from 60 cell lines of the National
Cancer Institute (NCI), USA, were correlated with the microarray-based mRNA expression …
Cancer Institute (NCI), USA, were correlated with the microarray-based mRNA expression …
Prediction of drug sensitivity and resistance of cancer by protein expression profiling
M Volm, R Koomagi, T Efferth - Cancer genomics & proteomics, 2004 - cgp.iiarjournals.org
Although the statistical probability of therapeutic success is known for larger groups of
cancer patients, the clinical response to chemotherapy of the individual patient remains …
cancer patients, the clinical response to chemotherapy of the individual patient remains …
A review of proteomics in cancer research
The most functional compartment encoded by the genome is proteome. Therefore study of
proteome ie proteomics is the promising approach in identification, separation and …
proteome ie proteomics is the promising approach in identification, separation and …