Vinblastine and vincristine are dimeric indole alkaloids derived from Catharanthus roseus (formerly:
Vinca rosea). Their monomeric precursor molecules are vindoline and catharanthine…

Biodegradable polymer based novel drug delivery systems have provided many avenues to
improve therapeutic efficacy and pharmacokinetic parameters of medicinal entities. Among …

Many natural products and derivatives thereof belong to the standard repertoire of cancer
chemotherapy. Examples are Vinca alkaloids, taxanes and camptothecins. In recent years, the …

Nitric oxide (NO) is a radical molecule produced by iNOS and plays a role in various physiological
and pathophysiological conditions including inflammatory diseases and cancer. In the …

Biodegradable polymers provided the opportunity to explore beyond conventional drug
delivery and turned out to be the focus of current drug delivery. In spite of availability of diverse …

Purpose: Drug resistance is a major obstacle in cancer chemotherapy. Although the statistical
probability of therapeutic success is known for larger patient groups from clinical therapy …

Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO 2 release profiles
with half-lives of SO 2 release varying from 2 to 63 min are reported. N-Benzyl-2,4-…

In contrast to western medicine (WM), traditional Chinese medicine (TCM) does not focus on
a single target but on multiple targets involved in a particular disease condition by applying …

A tremendous interest exists in the Western world in Traditional Chinese Medicine (TCM) with
rapidly increasing export rates of TCM products from China to Europe and USA. This led to …

The anti-malarial artesunate also exerts profound anti-cancer activity. The susceptibility of
tumor cells to artesunate can be enhanced by ferrous iron. The transferrin receptor (TfR) is …