User profiles for SUSAN D. KRANER
Susan KranerScientist III, Sanders Brown Center on Aging, University of Kentucky Verified email at uky.edu Cited by 4604 |
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons
Expression of the type II voltage-dependent sodium channel gene is restricted to neurons
by a silencer element active in nonneuronal cells. We have cloned cDNA coding for a …
by a silencer element active in nonneuronal cells. We have cloned cDNA coding for a …
Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling
…, I Baig, MP Murphy, H LeVine, SD Kraner… - Journal of …, 2009 - Soc Neuroscience
Upon activation by calcineurin, the nuclear factor of activated T-cells (NFAT) translocates to
the nucleus and guides the transcription of numerous molecules involved in inflammation …
the nucleus and guides the transcription of numerous molecules involved in inflammation …
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models
…, NM Porter, PW Landfield, SD Kraner - Journal of …, 2005 - Soc Neuroscience
Astrocyte reactivity (ie, activation) and associated neuroinflammation are increasingly
thought to contribute to neurodegenerative disease. However, the mechanisms that trigger …
thought to contribute to neurodegenerative disease. However, the mechanisms that trigger …
Silencing the type II sodium channel gene: a model for neural-specific gene regulation
Neural-specific expression of a sodium channel minigene has been shown to be mediated
by a 28 bp silencer element, REl, located in the 5’flanking region of the gene. This element is …
by a 28 bp silencer element, REl, located in the 5’flanking region of the gene. This element is …
Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats
…, KC Chen, J Popović, SD Kraner… - Proceedings of the …, 2014 - National Acad Sciences
Vitamin D is an important calcium-regulating hormone with diverse functions in numerous
tissues, including the brain. Increasing evidence suggests that vitamin D may play a role in …
tissues, including the brain. Increasing evidence suggests that vitamin D may play a role in …
Loss of electrical excitability in an animal model of acute quadriplegic myopathy
MM Rich, MJ Pinter, SD Kraner… - Annals of Neurology …, 1998 - Wiley Online Library
In rats treated with high‐dose corticosteroids, skeletal muscle that is denervated in vivo (steroid‐denervated
[S‐D]) develops electrical inexcitability similar to that seen in patients with …
[S‐D]) develops electrical inexcitability similar to that seen in patients with …
[HTML][HTML] Interleukin-1β-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity
Interleukin-1β (IL-1β) and the Ca 2+ /calmodulin-dependent protein phosphatase, calcineurin,
have each been shown to play an important role in neuroinflammation. However, whether …
have each been shown to play an important role in neuroinflammation. However, whether …
Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Aβ-bearing mice
Hyperexcitable neuronal networks are mechanistically linked to the pathologic and clinical
features of Alzheimer's disease (AD). Astrocytes are a primary defense against …
features of Alzheimer's disease (AD). Astrocytes are a primary defense against …
[HTML][HTML] Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia
…, ES Song, LD Brewer, CS Latimer, SD Kraner… - Acta neuropathologica …, 2014 - Springer
Mid-life obesity and type 2 diabetes mellitus (T2DM) confer a modest, increased risk for
Alzheimer’s disease (AD), though the underlying mechanisms are unknown. We have created a …
Alzheimer’s disease (AD), though the underlying mechanisms are unknown. We have created a …
Blockade of astrocytic calcineurin/NFAT signaling helps to normalize hippocampal synaptic function and plasticity in a rat model of traumatic brain injury
Increasing evidence suggests that the calcineurin (CN)-dependent transcription factor NFAT
(Nuclear Factor of Activated T cells) mediates deleterious effects of astrocytes in …
(Nuclear Factor of Activated T cells) mediates deleterious effects of astrocytes in …