User profiles for STEVEN G. CLARKE

Steven G. Clarke

Professor of Chemistry and Biochemistry, UCLA
Verified email at mbi.ucla.edu
Cited by 48961

[PDF][PDF] Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

…, J Chung, RSB Clark, PGH Clarke, SG Clarke… - Autophagy, 2008 - Taylor & Francis
Research in autophagy continues to accelerate, 1 and as a result many new scientists are
entering the field. Accordingly, it is important to establish a standard set of criteria for …

[HTML][HTML] Protein arginine methylation in mammals: who, what, and why

MT Bedford, SG Clarke - Molecular cell, 2009 - cell.com
The covalent marking of proteins by methyl group addition to arginine residues can promote
their recognition by binding partners or can modulate their biological activity. A small family …

[HTML][HTML] Uncovering the human methyltransferasome

TC Petrossian, SG Clarke - Molecular & Cellular Proteomics, 2011 - ASBMB
Clarke SG … Clarke SG … Clarke CF …

[HTML][HTML] Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming ω-NG-monomethylated arginine residues

…, T Sandberg, R Kelly, SG Clarke - Journal of Biological …, 2012 - ASBMB
Full-length human protein arginine methyltransferase 7 (PRMT7) expressed as a fusion protein
in Escherichia coli was initially found to generate only ω-N G -monomethylated arginine …

L-Ascorbate biosynthesis in higher plants: the role of VTC2

CL Linster, SG Clarke - Trends in plant science, 2008 - cell.com
In the past year, the last missing enzyme of the l-galactose pathway, the linear form of which
appears to represent the major biosynthetic route to l-ascorbate (vitamin C) in higher plants, …

[PDF][PDF] 2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling

…, DA Nathanson, A Lai, KF Faull, M Jiang, SG Clarke… - Cell metabolism, 2015 - cell.com
We discovered recently that the central metabolite α-ketoglutarate (α-KG) extends the
lifespan of C. elegans through inhibition of ATP synthase and TOR signaling. Here we find, …

[HTML][HTML] PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145

…, R Kelly, A Guo, W Li, SG Clarke… - Nature …, 2015 - nature.com
The human genome encodes a family of nine protein arginine methyltransferases (PRMT1–9),
whose members can catalyse three distinct types of methylation on arginine residues. …

[HTML][HTML] Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs

…, S Richard, MJ Comb, A Guo, SG Clarke… - Scientific reports, 2013 - nature.com
Arginine methylation is a common posttranslational modification that is found on both histone
and non-histone proteins. Three types of arginine methylation exist in mammalian cells: …

Protein methylation at the surface and buried deep: thinking outside the histone box

SG Clarke - Trends in biochemical sciences, 2013 - cell.com
Methylated lysine and arginine residues in histones represent a crucial part of the histone
code, and recognition of these methylated residues by protein interaction domains modulates …

[HTML][HTML] Arabidopsis VTC2 Encodes a GDP-l-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants*♦

…, LN Adler, BD Young, C Brenner, SG Clarke - Journal of Biological …, 2007 - ASBMB
The first committed step in the biosynthesis of l-ascorbate from d-glucose in plants requires
conversion of GDP-l-galactose to l-galactose 1-phosphate by a previously unidentified …