Protein kinase D (PKD) is a cytosolic serine/threonine kinase implicated in regulation of several
cellular processes such as response to oxidative stress, directed cell migration, invasion, …

Purpose: The tumor microenvironment plays a key role in cancer development and
progression and is involved in resistance to chemo- and immunotherapy. Cancer-associated …

Cellular dynamics are modeled by the 3D architecture and mechanics of the extracellular
matrix (ECM) and vice versa. These bidirectional cell‐ECM interactions are the basis for all …

NOD1 is an intracellular pathogen recognition receptor that contributes to anti-bacterial innate
immune responses, adaptive immunity and tissue homeostasis. NOD1-induced signaling …

Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and
tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is …

10.7554/eLife.35907.001 Protein kinase D (PKD) is a family of serine/threonine kinases that
is required for the structural integrity and function of the Golgi complex. Despite its …

Membrane trafficking is known to be coordinated by small GTPases, but the identity of their
regulators, the guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (…

Background/Aim: Dysregulation of mitochondrial pathways is implicated in several diseases,
including cancer. Notably, mitochondrial respiration and mitochondrial biogenesis are …

The lysine specific demethylase 1 (LSD1) plays a pivotal role in cellular differentiation by
regulating the expression of key developmental genes in concert with different coregulatory …

Phosphorylation is a ubiquitous mechanism by which signals are transduced in cells.
Protein kinases, enzymes that catalyze the phosphotransfer reaction are, themselves, often …