Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer
…, P Apostolou, I Konstanta, V Kotoula, S Lakis… - …, 2014 - academic.oup.com
Triple-negative (TN) breast cancer is an aggressive subtype of breast cancer associated with
a unique set of epidemiologic and genetic risk factors. We conducted a two-stage genome-…
a unique set of epidemiologic and genetic risk factors. We conducted a two-stage genome-…
[HTML][HTML] Tumors with high-density tumor infiltrating lymphocytes constitute a favorable entity in breast cancer: a pooled analysis of four prospective adjuvant trials
V Kotoula, K Chatzopoulos, S Lakis, Z Alexopoulou… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Background Tumor infiltrating lymphocytes (TILs) are considered in the prognosis of breast
cancer (BC) patients. Here, we investigated the prognostic/predictive effect of TILs in patients …
cancer (BC) patients. Here, we investigated the prognostic/predictive effect of TILs in patients …
[HTML][HTML] Technical validation of an RT-qPCR in vitro diagnostic test system for the determination of breast cancer molecular subtypes by quantification of ERBB2, ESR1, PGR …
…, K Schlombs, K Kaiser, E Veltrup, S Herlein, S Lakis… - BMC cancer, 2016 - Springer
Background MammaTyper is a novel CE-marked in vitro diagnostic RT-qPCR assay which
assigns routinely processed breast cancer specimens into the molecular subtypes Luminal A-…
assigns routinely processed breast cancer specimens into the molecular subtypes Luminal A-…
[HTML][HTML] Biological subtyping of early breast cancer: a study comparing RT-qPCR with immunohistochemistry
…, T Turpeenniemi-Hujanen, S Jyrkkiö, S Lakis… - Breast cancer research …, 2016 - Springer
The biological subtype of breast cancer influences the selection of systemic therapy.
Distinction between luminal A and B cancers depends on consistent assessment of Ki-67, but …
Distinction between luminal A and B cancers depends on consistent assessment of Ki-67, but …
[HTML][HTML] TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the …
…, F Zagouri, E Timotheadou, K Papadopoulou, S Lakis… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Background We investigated the impact of PIK3CA and TP53 mutations and p53 protein
status on the outcome of patients who had been treated with adjuvant anthracycline-taxane …
status on the outcome of patients who had been treated with adjuvant anthracycline-taxane …
The androgen receptor as a surrogate marker for molecular apocrine breast cancer subtyping
S Lakis, V Kotoula, AG Eleftheraki, A Batistatou… - The Breast, 2014 - Elsevier
The Androgen Receptor (AR) is a potential prognostic marker and therapeutic target in
breast cancer. We evaluated AR protein expression in high-risk breast cancer treated in the …
breast cancer. We evaluated AR protein expression in high-risk breast cancer treated in the …
Prognostic evaluation of epidermal growth factor receptor (EGFR) genotype and phenotype parameters in triple-negative breast cancers
…, K Papadopoulou, S Lakis… - Cancer genomics & …, 2017 - cgp.iiarjournals.org
Background: Epidermal growth factor receptor (EGFR) aberrations have been implicated in
the pathogenesis of triple-negative breast cancer (TNBC) but their impact on prognosis and, …
the pathogenesis of triple-negative breast cancer (TNBC) but their impact on prognosis and, …
[HTML][HTML] Tumor biomarker conversion between primary and metastatic breast cancer: mRNA assessment and its concordance with immunohistochemistry
…, A Hartkopf, P Sinn, Z Varga, B Sobottka, L Sotiris… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… Deutsch, 2 Andreas Hartkopf, 4 Peter Sinn, 5 Zsuzsanna Varga, 6 Bettina Sobottka, 6
Lakis Sotiris, 3 Florin-Andrei Taran, 4 Christoph Domschke, 1, 2 Andre Hennigs, 1, 2 Sara Y …
Lakis Sotiris, 3 Florin-Andrei Taran, 4 Christoph Domschke, 1, 2 Andre Hennigs, 1, 2 Sara Y …
The prognostic significance of WNT pathway in surgically-treated colorectal cancer: β-catenin expression predicts for disease-free survival
…, A Konstantara, V Kotoula, S Lakis… - Anticancer …, 2013 - ar.iiarjournals.org
Background: The wingless-type MMTV integration site family of proteins (WNT) pathway is
highly involved in colorectal cancer development. The aim of this study was to explore the …
highly involved in colorectal cancer development. The aim of this study was to explore the …
Prognostic subcellular Notch2, Notch3 and Jagged1 localization patterns in early triple-negative breast cancer
…, C Papadimitriou, G Lazaridis, S Lakis… - Anticancer …, 2017 - ar.iiarjournals.org
Background: The Notch pathway has been implicated in triple-negative breast cancer (TNBC).
Herein, we studied the subcellular localization of the less investigated Notch2 and Notch3 …
Herein, we studied the subcellular localization of the less investigated Notch2 and Notch3 …