Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing

M Zhang, S Hu, M Min, Y Ni, Z Lu, X Sun, J Wu, B Liu… - Gut, 2021 - gut.bmj.com
Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and
treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to …

Identification of a Tumor-Suppressive Human-Specific MicroRNA within the FHIT Tumor-Suppressor Gene

B Hu, X Ying, J Wang, J Piriyapongsa, IK Jordan… - Cancer research, 2014 - AACR
Loss or attenuated expression of the tumor-suppressor gene FHIT is associated paradoxically
with poor progression of human tumors. Fhit promotes apoptosis and regulates reactive …

[HTML][HTML] Gut metagenomes of type 2 diabetic patients have characteristic single-nucleotide polymorphism distribution in Bacteroides coprocola

Y Chen, Z Li, S Hu, J Zhang, J Wu, N Shao, X Bo, M Ni… - Microbiome, 2017 - Springer
Background Gut microbes play a critical role in human health and disease, and researchers
have begun to characterize their genomes, the so-called gut metagenome. Thus far, …

[HTML][HTML] A tumor-specific prognostic long non-coding RNA signature in gastric cancer

W Ren, J Zhang, W Li, Z Li, S Hu, J Suo… - Medical science monitor …, 2016 - ncbi.nlm.nih.gov
Background Aberrant expression of long non-coding RNAs (lncRNAs) is associated with
prognosis of gastric cancer, some of which could be further evaluated as potential biomarkers. …

[HTML][HTML] Transcriptional response profiles of paired tumor-normal samples offer novel perspectives in pan-cancer analysis

S Hu, H Yuan, Z Li, J Zhang, J Wu, Y Chen, Q Shi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Both tumor and adjacent normal tissues are valuable in cancer research. Transcriptional
response profiles represent the changes of gene expression levels between paired tumor and …

Up-regulation of FAM64A promotes epithelial-to-mesenchymal transition and enhances stemness features in breast cancer cells

…, L Qian, J Wu, D Lu, H Yuan, W Li, X Ying, S Hu - Biochemical and …, 2019 - Elsevier
FAM64A was found to be markedly up-regulated in tumor samples and associated with worse
overall survival in multiple cancer types, including breast cancer. However, the functional …

[HTML][HTML] Susceptibility factors of stomach for SARS-CoV-2 and treatment implication of mucosal protective agent in COVID-19

M Zhang, C Feng, X Zhang, S Hu, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Objectives: This work aims to study the gastrointestinal (GI) symptoms in severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2)-infected patients and the susceptibility factors …

[HTML][HTML] Mosaic integration and knowledge transfer of single-cell multimodal data with MIDAS

Z He, S Hu, Y Chen, S An, J Zhou, R Liu, J Shi… - Nature …, 2024 - nature.com
Integrating single-cell datasets produced by multiple omics technologies is essential for
defining cellular heterogeneity. Mosaic integration, in which different datasets share only some …

[HTML][HTML] miR-21-mediated radioresistance occurs via promoting repair of DNA double strand breaks

B Hu, X Wang, S Hu, X Ying, P Wang, X Zhang… - Journal of Biological …, 2017 - ASBMB
miR-21, as an oncogene that overexpresses in most human tumors, is involved in
radioresistance; however, the mechanism remains unclear. Here, we demonstrate that miR-21-…

MetaLogo: a heterogeneity-aware sequence logo generator and aligner

Y Chen, Z He, Y Men, G Dong, S Hu… - Briefings in …, 2022 - academic.oup.com
Sequence logos are used to visually display conservations and variations in short sequences.
They can indicate the fixed patterns or conserved motifs in a batch of DNA or protein …