DURING thymic development, T cells that can recognize foreign antigen in association with
self major histocompatibility complex (MHC) are selected for survival (positive selection) and …

The U box is a domain of ∼70 amino acids that is present in proteins from yeast to humans.
The prototype U box protein, yeast Ufd2, was identified as a ubiquitin chain assembly factor …

TRIM8 is a member of the protein family defined by the presence of a common domain structure
composed of a tripartite motif: a RING-finger, one or two B-box domains and a coiled-coil …

Given that expression of c-Myc is up-regulated in many human malignancies, targeted
inactivation of this oncoprotein is a potentially effective strategy for cancer treatment. The ubiquitin-…

A RING finger-containing protein (AO7) that binds ubiquitin-conjugating enzymes (E2s) and
is a substrate for E2-dependent ubiquitination was identified. Mutations of cation-…

The F‐box protein Skp2 mediates c‐Myc ubiquitylation by binding to the MB2 domain.
However, the turnover of c‐Myc is largely dependent on phosphorylation of threonine‐58 and …

The ubiquitin–proteasome pathway plays an important role in control of the abundance of
cell cycle regulators. Mice lacking Skp2, an F‐box protein and substrate recognition …

Emerging clinical evidence shows that the deregulation of ubiquitin-mediated degradation
of oncogene products or tumour suppressors is likely to be involved in the aetiology of …

β-catenin plays an essential role in the Wingless/Wnt signaling cascade and is a component
of the cadherin cell adhesion complex. Deregulation of β-catenin accumulation as a result …

Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have
various functions in cellular processes including intracellular signaling, development, …