Smad regulation in TGF-β signal transduction

A Moustakas, S Souchelnytskyi… - Journal of cell …, 2001 - journals.biologists.com
Smad proteins transduce signals from transforming growth factor-β (TGF-β) superfamily
ligands that regulate cell proliferation, differentiation and death through activation of receptor …

[HTML][HTML] TGF‐β receptor‐mediated signalling through Smad2, Smad3 and Smad4

A Nakao, T Imamura, S Souchelnytskyi… - The EMBO …, 1997 - embopress.org
Smad family members are newly identified essential intracellular signalling components of
the transforming growth factor‐β (TGF‐β) superfamily. Smad2 and Smad3 are structurally …

[HTML][HTML] Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling

S Souchelnytskyi, K Tamaki, U Engström… - Journal of Biological …, 1997 - ASBMB
Members of the Smad family of intracellular signal transducers are essential for transforming
growth factor-β (TGF-β) to exert its multifunctional effects. After activation of TGF-β receptors…

[HTML][HTML] The L45 loop in type I receptors for TGF-β family members is a critical determinant in specifying Smad isoform activation

U Persson, H Izumi, S Souchelnytskyi, S Itoh… - FEBS letters, 1998 - Elsevier
Transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMPs) signal via
distinct type I and type II receptors and Smad proteins. A nine amino acid sequence between …

Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site

…, F Cand, F Cruzalegui, C Wernstedt, S Souchelnytskyi… - Oncogene, 2007 - nature.com
Src-family tyrosine kinases are regulatory proteins that play a pivotal role in the disorganization
of cadherin-dependent cell–cell contacts. We previously showed that Src was associated …

Regulation of Smad signaling by protein kinase C

…, P Dijke, CH Heldin, S Souchelnytskyi - The FASEB …, 2001 - Wiley Online Library
Cross talk between transforming growth factor β (TGF‐β) serine/threonine kinase receptor
signaling and tyrosine kinase receptor signaling modulates cell responsiveness to …

Cancer biomarker discovery: current status and future perspectives

…, C Peitzsch, I Kurth, S Souchelnytskyi… - … journal of radiation …, 2014 - Taylor & Francis
Purpose: Cancer is a multigene disease which arises as a result of mutational and epigenetic
changes coupled with activation of complex signaling networks. The use of biomarkers for …

Frequent loss of SMAD4/DPC4 protein in colorectal cancers

…, E Avizienyte, P Kristo, H Järvinen, S Souchelnytskyi… - Gut, 2002 - gut.bmj.com
Background and aims: Loss of DNA sequences from chromosome 18q21 is a major genetic
change in colorectal tumorigenesis. Multiple genes have been identified in this area. One of …

Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas

…, I Gout, V Gryshkova, N Bhaskaran, S Souchelnytskyi… - Cancer immunity, 2008 - AACR
Mouse monoclonal antibody MX35 was developed against ovarian cancer. The antibody
showed homogeneous reactivity with approximately 90% of human ovarian epithelial cancers …

[HTML][HTML] Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-β receptors

S Souchelnytskyi, T Nakayama, A Nakao… - Journal of Biological …, 1998 - ASBMB
Members of the transforming growth factor-β (TGF-β) family transmit signals from membrane
to nucleus via intracellular proteins known as Smads. A subclass of Smad proteins has …