User profiles for SEONG-GYU KO

KO Seong-Gyu

Professor of College of Korean Medicine, Kyung Hee University
Verified email at khu.ac.kr
Cited by 7875

[HTML][HTML] Natural products for pancreatic cancer treatment: From traditional medicine to modern drug discovery

…, J Ha, J Kim, Y Cho, J Ahn, C Cheon, SH Kim, SG Ko… - Nutrients, 2021 - mdpi.com
Pancreatic cancer, the seventh most lethal cancer around the world, is considered complicated
cancer due to poor prognosis and difficulty in treatment. Despite all the conventional …

Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages

…, SK Park, HC Kim, H Bae, HM Kim, SG Ko… - Journal of …, 2009 - Elsevier
AIM OF THE STUDY: The root of Scutellaria baicalensis Georgi (Labiatae), also known as
Scutellariae Radix, possesses anticancer, antiviral, and anti-inflammatory properties. And it is …

Evidence-based management of herb-drug interaction in cancer chemotherapy

CW Cheng, W Fan, SG Ko, L Song, ZX Bian - Explore, 2010 - Elsevier
The fact that many cancer patients take herbal medicine, including Chinese herbal medicine,
together with chemotherapy is well known. The potential for side effects resulting from …

[HTML][HTML] Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells

TW Kim, SY Lee, M Kim, C Cheon, SG Ko - Cell death & disease, 2018 - nature.com
Kaempferol, a flavonoid, found in traditional medicine, fruits, and vegetables, and an HDAC
inhibitor, is a powerful anti-cancer reagent against various cancer cell lines. However, …

[HTML][HTML] Review deciphering potent therapeutic approaches targeting Notch signaling pathway in breast cancer

…, M Choi, SK Singh, HN Kang, MN Park, SG Ko… - Biomedicine & …, 2023 - Elsevier
In the current period of drug development, natural products have provided an unrivaled
supply of anticancer medications. By modifying the cancer microenvironment and various …

Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the IκB/NF-κB signal cascade in the human mast cell line HMC-1

…, HJ Jeong, HJ An, SJ Park, HR Kim, SG Ko… - European Journal of …, 2007 - Elsevier
Scopoletin (6-methoxy-7-hydroxycoumarin) is a coumarin compound and a pharmacologically
active agent that has been isolated from several plant species. However, as yet there is …

Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells

…, HS Seo, HS Choi, IH Choi, YC Shin, SG Ko - Archives of pharmacal …, 2011 - Springer
Ursolic acid (3-hydroxy-urs-12-en-28-oic acid) is a pentacyclic triterpenoid derived from
leaves, berries, fruits, and flowers of medicinal plants, such as Rosemarinus officinalis. Ursolic …

Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis

HJ Lee, HJ Lee, EO Lee, SG Ko, HS Bae, CH Kim… - Cancer letters, 2008 - Elsevier
Isorhamnetin is a flavanoid present in plants of the Polygonaceae family and is also an
immediate metabolite of quercetin in mammals. Since the plasma level of isorhamnetin is …

Induction of apoptosis by Saussurea lappa and Pharbitis nil on AGS gastric cancer cells

SG Ko, SH Koh, CY Jun, CG Nam, HS Bae… - Biological and …, 2004 - jstage.jst.go.jp
MATERIALS AND METHODS Cell Culture The AGS human gastric carcinoma cell line was
obtained from American Type Culture Collection (ATCC, Rockville, MD, USA) and grown in …

[HTML][HTML] Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2 …

…, H Hur, BH Jang, YC Shin, SG Ko - Oncology …, 2016 - spandidos-publications.com
Flavonoids are assumed to exert beneficial effects in different types of cancers at high
concentrations. Yet, their molecular mechanisms of action remain unknown. The present study …