User profiles for RICHARD J. ROMAN

Richard J Roman

University of mississippi medical center
Verified email at umc.edu
Cited by 31645

P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function

RJ Roman - Physiological reviews, 2002 - journals.physiology.org
Recent studies have indicated that arachidonic acid is primarily metabolized by
cytochromeP-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-…

Astrocytes and the regulation of cerebral blood flow

RC Koehler, RJ Roman, DR Harder - Trends in neurosciences, 2009 - cell.com
Moment-to-moment changes in local neuronal activity lead to dynamic changes in cerebral
blood flow. Emerging evidence implicates astrocytes as one of the key players in …

Production of 20-HETE and its role in autoregulation of cerebral blood flow

…, JR Falck, H Okamoto, RJ Roman… - Circulation …, 2000 - Am Heart Assoc
In the brain, pressure-induced myogenic constriction of cerebral arteriolar muscle contributes
to autoregulation of cerebral blood flow (CBF). This study examined the role of 20-HETE in …

Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats

…, A Dahly, K Ditter, M Mistry, RJ Roman - Journal of …, 2003 - journals.lww.com
… Correspondence and requests for reprints to Richard J. Roman, Department of Physiology,
Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, …

20-HETE is an endogenous inhibitor of the large-conductance Ca (2+)-activated K+ channel in renal arterioles

…, DR Harder, RJ Roman - American Journal …, 1996 - journals.physiology.org
The present study examined the effects of 20-hydroxyeicosatetraenoic acid (20-HETE) and
17-octadecynoic acid (17-ODYA), an inhibitor of the metabolism of arachidonic acid by P-450…

Identification of putative gene based markers of renal toxicity.

…, RJ Roman, M Lawton, J Kramer… - Environmental …, 2004 - ehp.niehs.nih.gov
This study, designed and conducted as part of the International Life Sciences Institute
working group on the Application of Genomics and Proteomics, examined the changes in the …

Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle

…, YH Ma, JR Falck, RJ Roman… - American Journal …, 1992 - journals.physiology.org
Microsomal preparations of cat brain incubated with [14C]arachidonic acid produced
epoxyeicosatrienoic acids (EETs) that eluted with the same retention times as synthetically …

The role of the kidney in hypertension

AW Cowley, RJ Roman - Jama, 1996 - jamanetwork.com
DESPITE unequivocal evidence that renal function is altered in hypertension, certain important
issues are unresolved. The most controversial area is whether the observed changes in …

Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets

W Lv, GW Booz, Y Wang, F Fan, RJ Roman - European journal of …, 2018 - Elsevier
Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal
fibrosis is the final common pathway of progressive kidney disease irrespective of the initial …

Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites

…, NJ Alkayed, AR Lange, D Gebremedhin, RJ Roman - Stroke, 1998 - Am Heart Assoc
Background—Cerebral blood flow is tightly coupled to neuronal metabolic activity, a
phenomenon referred to as functional hyperemia. The mechanisms underlying functional …