[HTML][HTML] Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA

L Benešová, T Hálková, R Ptáčková… - World Journal of …, 2019 - ncbi.nlm.nih.gov
BACKGROUND One of the most notable applications for circulating tumor DNA (ctDNA)
detection in peripheral blood of patients with metastatic colorectal cancer (mCRC) is a long-term …

Combination of circulating tumour DNA and 18F-FDG PET/CT for precision monitoring of therapy response in patients with advanced non-small cell lung cancer: a …

…, M Svaton, L Benesova, R Ptackova… - Cancer Genomics & …, 2022 - cgp.iiarjournals.org
Background/Aim: Circulating tumour DNA (ctDNA) represents an emerging biomarker in non-small
cell lung cancer (NSCLC). We focused on the combination of ctDNA and positron …

Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency

…, YM Mueller, MJ Najafzadeh, J Kang, R Ptackova… - Science …, 2020 - science.org
A leading pharmacological strategy toward HIV cure requires “shock” or activation of HIV
gene expression in latently infected cells with latency reversal agents (LRAs) followed by their …

Photo-initiated crosslinking extends mapping of the protein–protein interface to membrane-embedded portions of cytochromes P450 2B4 and b5

T Ječmen, R Ptáčková, V Černá, H Dračínská, P Hodek… - Methods, 2015 - Elsevier
Protein–protein interactions play a central role in the regulation of many biochemical processes
(eg the system participating in enzyme catalysis). Therefore, a deeper understanding of …

[HTML][HTML] Detection and quantification of ctDNA for longitudinal monitoring of treatment in non-small cell lung cancer patients using a universal mutant detection assay …

L Benesova, R Ptackova, T Halkova… - … & Oncology Research, 2022 - por-journal.com
Background: Observation of anticancer therapy effect by monitoring of minimal residual
disease (MRD) is becoming an important tool in management of non-small cell lung cancer (…

[HTML][HTML] The Application of an Emerging Technique for Protein–Protein Interaction Interface Mapping: The Combination of Photo-Initiated Cross-Linking Protein …

R Ptáčková, T Ječmen, P Novák, J Hudeček… - International Journal of …, 2014 - mdpi.com
Protein–protein interaction was investigated using a protein nanoprobe capable of photo-initiated
cross-linking in combination with high-resolution and tandem mass spectrometry. This …

[HTML][HTML] Circulating Tumor DNA correlates with Lactate Dehydrogenase, CYFRA 21-1, and CRP levels in patients with advanced NSCLC

M Buresova, L Benesova, M Minarik, R Ptackova… - Journal of …, 2023 - ncbi.nlm.nih.gov
Purpose: To investigate potential association between selected tumor markers and
laboratory parameters (lactate dehydrogenase [LDH], neutrophils, hemoglobin, neutrophils, …

[PDF][PDF] Quantification of interactions between cytochrome P450 2B4 and cytochrome b

T Ječmen, R Ptáčková, D Kavan, V Černá… - Neuroendocrinology …, 2014 - nel.altamira.sk
OBJECTIVES: The mammalian mixed function oxidase (MFO) system participates in hydroxylation
of many hydrophobic endogenous compounds as well as xenobiotics such as drugs …

[HTML][HTML] Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma

T Hálková, R Ptáčková, A Semyakina, Š Suchánek… - Cancers, 2022 - mdpi.com
Simple Summary Identifying patients with an increased risk of early recurrence of colorectal
lesions is still a problem. In our study, we focused on improving this identification by …

Application of oncoMonitor™ ctDNA tracking technology for monitoring of therapy and early detection of recurrence in metastatic colorectal cancer

M Minarik, B Belsanova, R Ptackova, T Halkova… - Cancer Research, 2020 - AACR
Introduction: Liquid biopsy based on detection of circulating tumor DNA (circulating-tumor
DNA, ctDNA) is finding new applications in clinical management of solid cancers. From the …