mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5

…, I Hauber, S Horn, P Abramowski… - Nucleic acids …, 2015 - academic.oup.com
Homozygosity for a natural deletion variant of the HIV-coreceptor molecule CCR5, CCR5Δ32,
confers resistance toward HIV infection. Allogeneic stem cell transplantation from a …

[HTML][HTML] Avoidance of on-target off-tumor activation using a co-stimulation-only chimeric antigen receptor

J Fisher, P Abramowski, NDW Don, B Flutter… - Molecular Therapy, 2017 - cell.com
Chimeric antigen receptors (CARs) combine T cell activation with antibody-mediated tumor
antigen specificity, bypassing the need for T cell receptor (TCR) ligation. A limitation of CAR …

Combined targeting of soluble latent TGF-ss and a solid tumor-associated antigen with adapter CAR T cells

…, M von Bergwelt-Baildon, P Abramowski… - …, 2022 - Taylor & Francis
Solid tumors consist of malignant and nonmalignant cells that together create the local
tumor microenvironment (TME). Additionally, the TME is characterized by the expression of …

[PDF][PDF] Cellular barcoding identifies clonal substitution as a hallmark of local recurrence in a surgical model of head and neck squamous cell carcinoma

V Roh, P Abramowski, A Hiou-Feige, K Cornils… - Cell reports, 2018 - cell.com
Local recurrence after surgery for head and neck squamous cell carcinoma (HNSCC) remains
a common event associated with a dismal prognosis. Improving this outcome requires a …

Engineering γδT cells limits tonic signaling associated with chimeric antigen receptors

…, DW Don, M Barisa, MO Hurtado, P Abramowski… - Science …, 2019 - science.org
Despite the benefits of chimeric antigen receptor (CAR)–T cell therapies against lymphoid
malignancies, responses in solid tumors have been more limited and off-target toxicities have …

[HTML][HTML] A truncation variant of the cation channel P2RX5 is upregulated during T cell activation

P Abramowski, C Ogrodowczyk, R Martin, O Pongs - PLoS One, 2014 - journals.plos.org
Members of the P2X family of ligand-gated cation channels (P2RX) are expressed by
various cell types including neurons, smooth- and cardiac muscle cells, and leukocytes. The …

Mesenchymal stromal/stem cells do not ameliorate experimental autoimmune encephalomyelitis and are not detectable in the central nervous system of transplanted …

P Abramowski, S Krasemann, T Ernst… - Stem Cells and …, 2016 - liebertpub.com
Mesenchymal stromal/stem cells (MSCs) constitute progenitor cells that can be isolated from
different tissues. Based on their immunomodulatory and neuroprotective functions, MSC-…

Combined application of RGB marking and mass spectrometric imaging facilitates detection of tumor heterogeneity

P Abramowski, O Kraus, S Rohn… - Cancer genomics & …, 2015 - cgp.iiarjournals.org
Cancer-cell heterogeneity dramatically influences treatment success, but escapes detection
by classical histology. Mass-spectrometric imaging (MSI) represents a powerful method for …

[HTML][HTML] The orally available, synthetic ether lipid edelfosine inhibits T cell proliferation and induces a type I interferon response

P Abramowski, B Otto, R Martin - PLoS One, 2014 - journals.plos.org
The drug edelfosine is a synthetic analog of 2-lysophosphatidylcholine. Edelfosine is
incorporated by highly proliferating cells, eg activated immune cells. It acts on cellular membranes …

Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis

P Abramowski, K Steinbach, AR Zander… - Journal of …, 2014 - Elsevier
The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating
cells, eg activated immune cells. We examined mechanisms of action of edelfosine on …