Design of sequence-specific DNA-binding molecules

PB Dervan - Science, 1986 - science.org
Base sequence information can be stored in the local structure of right-handed double-helical
DNA (B-DNA). The question arises as to whether a set of rules for the three-dimensional …

[PDF][PDF] Molecular recognition of DNA by small molecules

PB Dervan - Bioorganic & medicinal chemistry, 2001 - dervan.caltech.edu
Chemists, like artists, are able to construct new threedimensional objects, molecules and
materials that exist only in the mind of a person. I became interested in creating novel …

Sequence-specific cleavage of double helical DNA by triple helix formation

HE Moser, PB Dervan - Science, 1987 - science.org
Homopyrimidine oligodeoxyribonucleotides with EDTA⋅Fe attached at a single position bind
the corresponding homopyrimidine-homopurine tracts within large double-stranded DNA …

Second structural motif for recognition of DNA by oligonucleotide-directed triple-helix formation

PA Beal, PB Dervan - Science, 1991 - science.org
Relative orientations of the DNA strands within a purine⋅purine⋅pyrimidine triple helix
have been determined by affinity cleaving. A purine-rich oligonucleotide bound in the major …

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

PB Dervan, BS Edelson - Current opinion in structural biology, 2003 - Elsevier
… Author links open overlay panel Peter B Dervan , Benjamin S Edelson … (e,f) H-pin and
U-pin: compared to their nonlinked analogs, H-pins and U-pins exhibit higher binding affinity …

Recognition of the four Watson–Crick base pairs in the DNA minor groove by synthetic ligands

…, JW Szewczyk, JM Turner, EE Baird, PB Dervan - Nature, 1998 - nature.com
The design of synthetic ligands that read the information stored in the DNA double helix has
been a long-standing goal at the interface of chemistry and biology 1 , 2 , 3 , 4 , 5 . Cell-…

Regulation of gene expression by small molecules

…, L Neely, JW Trauger, EE Baird, PB Dervan - Nature, 1997 - nature.com
Small molecules that target specific DNA sequences have the potential to control gene
expression. Ligands designed for therapeutic application must bind any predetermined DNA …

Recognition of DNA by designed ligands at subnanomolar concentrations

JW Trauger, EE Baird, PB Dervan - Nature, 1996 - nature.com
SMALL molecules that specifically bind with high affinity to any predetermined DNA sequence
in the human genome would be useful tools in molecular biology and potentially in human …

Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids

EE Baird, PB Dervan - Journal of the American Chemical Society, 1996 - ACS Publications
The solid phase synthesis of sequence specific DNA binding polyamides containing N-methylimidazole
(Im) and N-methylpyrrole (Py) amino acids is described. Two monomer building …

Cleavage of DNA with methidiumpropyl-EDTA-iron (II): reaction conditions and product analyses

RP Hertzberg, PB Dervan - Biochemistry, 1984 - ACS Publications
Materials and Methods Materials. Blenoxane, a clinical bleomycin sulfate, was generously
supplied by Bristol Laboratories. Thiobarbituric f From the Division of Chemistry and Chemical …