User profiles for NEILL PATANI

Neill Patani

Consultant Oncoplastic Surgeon (UCLH), Hon Associate Professor (UCL), Postdoctoral …
Verified email at nhs.net
Cited by 2593

Biomarkers for the clinical management of breast cancer: international perspective

N Patani, LA Martin, M Dowsett - International journal of cancer, 2013 - Wiley Online Library
The higher incidence of breast cancer in developed countries has been tempered by reductions
in mortality, largely attributable to mammographic screening programmes and advances …

[HTML][HTML] Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance

…, M Hills, I Garcia-Murillas, C Fribbens, N Patani… - Nature …, 2017 - nature.com
Resistance to endocrine therapy remains a major clinical problem in breast cancer. Genetic
studies highlight the potential role of estrogen receptor-α (ESR1) mutations, which show …

[HTML][HTML] Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer

…, A Mendez-Lucas, C MacLachlan, N Patani… - Nature …, 2023 - nature.com
Tumors are intrinsically heterogeneous and it is well established that this directs their
evolution, hinders their classification and frustrates therapy 1 , 2 – 3 . Consequently, spatially …

Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer

N Patani, WG Jiang, RF Newbold… - Anticancer research, 2011 - ar.iiarjournals.org
Background: Epigenetic regulation of gene expression is under normal circumstances
tightly controlled by the specific methylation of cytosine residues in CpG dinucleotides and …

[HTML][HTML] The mRNA expression of SATB1 and SATB2 in human breast cancer

N Patani, W Jiang, R Mansel, R Newbold… - Cancer cell …, 2009 - Springer
Background SATB1 is a nuclear protein that has been recently reported to be a 'genome
organizer' which delineates specific epigenetic modifications at target gene loci, directly up-…

[HTML][HTML] Oncological outcome and patient satisfaction with skin-sparing mastectomy and immediate breast reconstruction: a prospective observational study

S Reefy, N Patani, A Anderson, G Burgoyne, H Osman… - BMC cancer, 2010 - Springer
Background The management of early breast cancer (BC) with skin-sparing mastectomy (SSM)
and immediate breast reconstruction (IBR) is not based on level-1 evidence. In this study, …

Oncological and aesthetic considerations of skin-sparing mastectomy

N Patani, K Mokbel - Breast cancer research and treatment, 2008 - Springer
Aim To review the oncological safety and aesthetic value of skin-sparing mastectomy (SSM)
for invasive breast cancer (IBC) and ductal carcinoma in-situ (DCIS). Controversies …

[HTML][HTML] Defining a metabolic landscape of tumours: genome meets metabolism

C Seth Nanda, SV Venkateswaran, N Patani… - British journal of …, 2020 - nature.com
Cancer is a complex disease of multiple alterations occuring at the epigenomic, genomic,
transcriptomic, proteomic and/or metabolic levels. The contribution of genetic mutations in …

The role of caveolin-1 in human breast cancer

N Patani, LA Martin, JS Reis-Filho… - Breast cancer research and …, 2012 - Springer
Caveolin-1 is the essential constituent protein of specialised plasma membrane invaginations
called caveolae. The unique topology of caveolin-1 facilitates the role of caveolae as …

Oncological safety and patient satisfaction with skin-sparing mastectomy and immediate breast reconstruction

N Patani, H Devalia, A Anderson, K Mokbel - Surgical oncology, 2008 - Elsevier
INTRODUCTION: The management of early breast cancer with skin-sparing mastectomy (SSM)
and immediate breast reconstruction (IBR) is not based on evidence from randomised …