Despite promising preclinical studies with the cyclin-dependent kinase inhibitor flavopiridol
in chronic lymphocytic leukemia (CLL) and other diseases, previous clinical trials with this …

Extracellular vesicles (EVs) are under evaluation as therapeutics or as vehicles for drug
delivery. Preclinical studies of EVs often use mice or other animal models to assess efficacy and …

Purpose Biliary cancers (BCs) carry a poor prognosis, but targeting the RAS/RAF/mitogen-activated
protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) pathway is of …

Purpose Patients with chronic lymphocytic leukemia (CLL) with high-risk genomic features
achieve poor outcomes with traditional therapies. A phase I study of a pharmacokinetically …

Patients with advanced hepatocellular carcinoma (HCC) face a dismal prognosis because
of a lack of any effective therapies. To address this situation, we conducted a preclinical …

Previous cell-penetrating peptides (CPPs) generally have low cytosolic delivery efficiencies,
because of inefficient endosomal escape. In this study, a family of small, amphipathic cyclic …

Despite widespread use in pharmacokinetic, drug metabolism, and pesticide residue studies,
little is known about the factors governing response during reversed-phase liquid …

We previously reported interim results of a phase 1 trial in patients with chronic lymphocytic
leukemia (CLL) whereby flavopiridol was administered intravenously as a 30-minute bolus …

The partial agonist activity of a selective androgen receptor modulator (SARM) in the prostate
was demonstrated in orchidectomized rats. In the current study, we characterized the full …

The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate
progress in the new field of extracellular RNA (exRNA) biology and to establish whether …