Stem cells undergo a shift in metabolic substrate utilization during specification and/or
differentiation, a process that has been termed metabolic reprogramming. Here, we report that …

Hematopoietic progenitors undergo differentiation while navigating several cell division cycles,
but it is unknown whether these two processes are coupled. We addressed this question …

The study of erythropoiesis aims to understand how red cells are formed from earlier
hematopoietic and erythroid progenitors. Specifically, the rate of red cell formation is regulated by …

Delay of cell cycle progression in response to double‐strand DNA breaks (DSBs) is critical
to allow time for DNA repair and prevent cellular transformation. Here, we show that the p38 …

Erythropoiesis maintains a stable hematocrit and tissue oxygenation in the basal state, while
mounting a stress response that accelerates red cell production in anemia, blood loss or …

Survival signaling by the erythropoietin (Epo) receptor (EpoR) is essential for erythropoiesis
and for its acceleration in hypoxic stress. Several apparently redundant EpoR survival …

Erythropoietin (Epo)-induced Stat5 phosphorylation (p-Stat5) is essential for both basal
erythropoiesis and for its acceleration during hypoxic stress. A key challenge lies in …

Erythropoiesis is regulated through a long-range negative feedback loop, whereby tissue
hypoxia stimulates erythropoietin (Epo) secretion, which promotes an increase in …

The bromodomain and extraterminal (BET) proteins recognize acetylated lysine residues on
histone tails and recruit transcriptional machinery to promote gene expression. The BET …

Following reports by ENCyclopedia Of DNA Elements (ENCODE; GENCODE) Consortium
and others, it is now fairly evident that the majority (70–80%) of the mammalian genome has …