User profiles for MARTIN DUGAS

Martin Dugas

Professor of Medical Informatics, Heidelberg University
Verified email at med.uni-heidelberg.de
Cited by 22085

Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

K Ghoreschi, P Thomas, S Breit, M Dugas… - Nature medicine, 2003 - nature.com
Selective skewing of autoreactive interferon-γ (IFN-γ)-producing T helper cells (Th1) toward
an interleukin-4 (IL-4)-producing (Th2) phenotype can in experimental animals alleviate …

Electronic health records: new opportunities for clinical research

…, B Claerhout, C Daniel, M Dugas… - Journal of internal …, 2013 - Wiley Online Library
Clinical research is on the threshold of a new era in which electronic health records ( EHR s)
are gaining an important novel supporting role. Whilst EHR s used for routine clinical care …

Detection of significantly differentially methylated regions in targeted bisulfite sequencing data

K Hebestreit, M Dugas, HU Klein - Bioinformatics, 2013 - academic.oup.com
Motivation: Bisulfite sequencing is currently the gold standard to obtain genome-wide DNA
methylation profiles in eukaryotes. In contrast to the rapid development of appropriate pre-…

[HTML][HTML] Benchmarking atlas-level data integration in single-cell genomics

…, MF Müller, DC Strobl, L Zappia, M Dugas… - Nature …, 2022 - nature.com
Single-cell atlases often include samples that span locations, laboratories and conditions,
leading to complex, nested batch effects in data. Thus, joint analysis of atlas datasets requires …

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

…, L Marton, P Woster, MD Minden, M Dugas… - Nature medicine, 2012 - nature.com
Acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid
leukemia (AML), characterized by the t(15;17)-associated PML-RARA fusion, has been …

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype

…, HU Klein, M Dugas… - Blood, The Journal …, 2011 - ashpublications.org
Among acute myeloid leukemia (AML) patients with a normal karyotype (CN-AML), NPM1
and CEBPA mutations define World Health Organization 2008 provisional entities accounting …

[PDF][PDF] Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting …

…, B Kazak, F Dicker, S Schnittger, M Dugas… - Journal of clinical …, 2010 - researchgate.net
Purpose Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy
that is characterized by features of both a myeloproliferative neoplasm and a myelodysplastic …

Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications

…, M Gehlhaar, C Walter, M Dugas… - Blood, The Journal …, 2014 - ashpublications.org
Mutations in the cohesin complex are novel, genetic lesions in acute myeloid leukemia (AML)
that are not well characterized. In this study, we analyzed the frequency, clinical, and …

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and …

S Schnittger, C Schoch, M Dugas… - Blood, The Journal …, 2002 - ashpublications.org
FLT3 length mutation (FLT3-LM) is a molecular marker potentially useful for the characterization
of acute myeloid leukemia (AML). To evaluate the distribution of FLT3-LM within biologic …

[PDF][PDF] Inherited and somatic defects in DDX41 in myeloid neoplasms

…, DA Pollyea, U Krug, WE Berdel, HU Klein, M Dugas… - Cancer cell, 2015 - cell.com
Most cases of adult myeloid neoplasms are routinely assumed to be sporadic. Here, we
describe an adult familial acute myeloid leukemia (AML) syndrome caused by germline …