User profiles for MARTIN DUGAS
Martin DugasProfessor of Medical Informatics, Heidelberg University Verified email at med.uni-heidelberg.de Cited by 22085 |
Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
K Ghoreschi, P Thomas, S Breit, M Dugas… - Nature medicine, 2003 - nature.com
Selective skewing of autoreactive interferon-γ (IFN-γ)-producing T helper cells (Th1) toward
an interleukin-4 (IL-4)-producing (Th2) phenotype can in experimental animals alleviate …
an interleukin-4 (IL-4)-producing (Th2) phenotype can in experimental animals alleviate …
Electronic health records: new opportunities for clinical research
Clinical research is on the threshold of a new era in which electronic health records ( EHR s)
are gaining an important novel supporting role. Whilst EHR s used for routine clinical care …
are gaining an important novel supporting role. Whilst EHR s used for routine clinical care …
Detection of significantly differentially methylated regions in targeted bisulfite sequencing data
Motivation: Bisulfite sequencing is currently the gold standard to obtain genome-wide DNA
methylation profiles in eukaryotes. In contrast to the rapid development of appropriate pre-…
methylation profiles in eukaryotes. In contrast to the rapid development of appropriate pre-…
[HTML][HTML] Benchmarking atlas-level data integration in single-cell genomics
Single-cell atlases often include samples that span locations, laboratories and conditions,
leading to complex, nested batch effects in data. Thus, joint analysis of atlas datasets requires …
leading to complex, nested batch effects in data. Thus, joint analysis of atlas datasets requires …
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
Acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid
leukemia (AML), characterized by the t(15;17)-associated PML-RARA fusion, has been …
leukemia (AML), characterized by the t(15;17)-associated PML-RARA fusion, has been …
Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype
Among acute myeloid leukemia (AML) patients with a normal karyotype (CN-AML), NPM1
and CEBPA mutations define World Health Organization 2008 provisional entities accounting …
and CEBPA mutations define World Health Organization 2008 provisional entities accounting …
[PDF][PDF] Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting …
…, B Kazak, F Dicker, S Schnittger, M Dugas… - Journal of clinical …, 2010 - researchgate.net
Purpose Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy
that is characterized by features of both a myeloproliferative neoplasm and a myelodysplastic …
that is characterized by features of both a myeloproliferative neoplasm and a myelodysplastic …
Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications
…, M Gehlhaar, C Walter, M Dugas… - Blood, The Journal …, 2014 - ashpublications.org
Mutations in the cohesin complex are novel, genetic lesions in acute myeloid leukemia (AML)
that are not well characterized. In this study, we analyzed the frequency, clinical, and …
that are not well characterized. In this study, we analyzed the frequency, clinical, and …
Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and …
S Schnittger, C Schoch, M Dugas… - Blood, The Journal …, 2002 - ashpublications.org
FLT3 length mutation (FLT3-LM) is a molecular marker potentially useful for the characterization
of acute myeloid leukemia (AML). To evaluate the distribution of FLT3-LM within biologic …
of acute myeloid leukemia (AML). To evaluate the distribution of FLT3-LM within biologic …
[PDF][PDF] Inherited and somatic defects in DDX41 in myeloid neoplasms
Most cases of adult myeloid neoplasms are routinely assumed to be sporadic. Here, we
describe an adult familial acute myeloid leukemia (AML) syndrome caused by germline …
describe an adult familial acute myeloid leukemia (AML) syndrome caused by germline …