SOX2 expression and amplification in gliomas and glioma cell lines

L Annovazzi, M Mellai, V Caldera… - Cancer genomics & …, 2011 - cgp.iiarjournals.org
Background: The transcription factor SOX2 controls gene expression during development
and has roles in both neurogenesis and gliogenesis. Materials and Methods: The current …

[HTML][HTML] Glioblastoma: microenvironment and niche concept

…, L Annovazzi, C Casalone, C Corona, M Mellai - Cancers, 2018 - mdpi.com
The niche concept was originally developed to describe the location of normal neural stem
cells (NSCs) in the subependymal layer of the sub-ventricular zone. In this paper, its …

IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors

M Mellai, A Piazzi, V Caldera, O Monzeglio… - Journal of neuro …, 2011 - Springer
A total of 343 brain tumors were studied for IDH1 and IDH2 mutations by direct sequencing
and for protein expression by immunohistochemistry with mIDH1 R132H antibody. Of these, …

Solid lipid nanoparticles for potential doxorubicin delivery in glioblastoma treatment: preliminary in vitro studies

…, D Schiffer, L Annovazzi, V Caldera, M Mellai… - Journal of …, 2014 - Elsevier
The major obstacle to glioblastoma pharmacological therapy is the overcoming of the blood–brain
barrier (BBB). In literature, several strategies have been proposed to overcome the …

[HTML][HTML] Chemotherapeutic drugs: DNA damage and repair in glioblastoma

L Annovazzi, M Mellai, D Schiffer - Cancers, 2017 - mdpi.com
Despite improvements in therapeutic strategies, glioblastoma (GB) remains one of the most
lethal cancers. The presence of the blood–brain barrier, the infiltrative nature of the tumor …

Positive-charged solid lipid nanoparticles as paclitaxel drug delivery system in glioblastoma treatment

…, M Lanotte, L Annovazzi, V Caldera, M Mellai… - European journal of …, 2014 - Elsevier
Paclitaxel loaded solid lipid nanoparticles (SLN) of behenic acid were prepared with the
coacervation technique. Generally, spherical shaped SLN with mean diameters in the range 300…

WNT/β-catenin signaling pathway and downstream modulators in low-and high-grade glioma

…, P Cassoni, A Melcarne, M Mellai… - Cancer genomics & …, 2016 - cgp.iiarjournals.org
Background: Aberrant activation of the canonical Wingless-type MMTV integration site family
(WNT)/β-catenin signaling pathway is critical for gliomas. Materials and Methods: In 74 …

mTOR, S6 and AKT expression in relation to proliferation and apoptosis/autophagy in glioma

L Annovazzi, M Mellai, V Caldera, G Valente… - Anticancer …, 2009 - ar.iiarjournals.org
Background: The mammalian target of rapamycin (mTOR) controls cell growth through protein
synthesis regulation. It can be activated by protein kinase B (AKT) or through ribosomal …

[HTML][HTML] Solid lipid nanoparticles carrying temozolomide for melanoma treatment. Preliminary in vitro and in vivo studies

…, E Biasibetti, D Schiffer, M Mellai… - International journal of …, 2018 - mdpi.com
Aim: To develop an innovative delivery system for temozolomide (TMZ) in solid lipid
nanoparticles (SLN), which has been preliminarily investigated for the treatment of melanoma. …

Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/β-catenin pathway

…, V Caldera, I Campia, J Kopecka, M Mellai… - Neuro …, 2013 - academic.oup.com
Background Glioblastoma multiforme stem cells display a highly chemoresistant phenotype,
whose molecular basis is poorly known. We aim to clarify this issue and to investigate the …