Purpose Malignant rhabdoid tumors (MRTs) are deadly embryonal tumors of the infancy.
With poor survival and modest response to available therapies, more effective and less toxic …

Histological and molecular characterization is essential for the diagnosis of pediatric brain
tumors. In the pineal region tumors, it is necessary to remove a sufficient tumor volume to …

Background Pediatric low-grade gliomas (P-LGG) consist of a mixed group of brain tumors
that correspond to the majority of CNS tumors in children. Notably, they may exhibit …

To date, several studies have described the mechanism of resistance to first‐ or second‐generation
anaplastic lymphoma kinase (ALK) inhibitors. Secondary ALK mutations, ALK gene …

The pungent principles of Capsicum annuum includes at least five closely related compounds.
Four of these pungent compounds‐capsaicin, dihydrocapsaicin, nordihydrocapsaicin and …

Glioblastoma (GBM) is pathologically characterized by highly malignant neoplastic cells,
focal necrosis and aberrant blood vessels composed of disorganized endothelial cells and …

Simple Summary By examining the detailed molecular oncogenic mechanisms of KLC1-ROS1
fusion, the function of a novel RTK fusion was investigated to discover novel therapeutic …

Although orbital tumors involving the optic nerve are rare, it is well-known that they are very
likely to cause serious visual impairment in a patient. Unfortunately, at present, there are no …

Background Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal brain
tumor that occurs mainly in early childhood. Although most of the tumors are characterized …

A 34-year-old female presented with trigeminal neuralgia caused by a venous malformation
in the right cerebello-pontine region. Computed tomography and magnetic resonance …