User profiles for MARILENA M. BOURDAKOU
Marilena BourdakouPostdoctoral Fellow and Visiting Scientist at Cyprus Institute of Neurology and Genetics Verified email at cing.ac.cy Cited by 409 |
Systems bioinformatics: increasing precision of computational diagnostics and therapeutics through network-based approaches
…, K Sokratous, MM Bourdakou… - Briefings in …, 2019 - academic.oup.com
Abstract Systems Bioinformatics is a relatively new approach, which lies in the intersection
of systems biology and classical bioinformatics. It focuses on integrating information across …
of systems biology and classical bioinformatics. It focuses on integrating information across …
Bioinformatics methods in drug repurposing for Alzheimer's disease
JC Siavelis, MM Bourdakou… - Briefings in …, 2016 - academic.oup.com
Alarming epidemiological features of Alzheimer’s disease impose curative treatment rather
than symptomatic relief. Drug repurposing, that is reappraisal of a substance’s indications …
than symptomatic relief. Drug repurposing, that is reappraisal of a substance’s indications …
[HTML][HTML] Generalized linear models provide a measure of virulence for specific mutations in SARS-CoV-2 strains
This study aims to highlight SARS-COV-2 mutations which are associated with increased or
decreased viral virulence. We utilize genetic data from all strains available from GISAID and …
decreased viral virulence. We utilize genetic data from all strains available from GISAID and …
Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is undeniably
the most severe global health emergency since the 1918 Influenza outbreak. Depending …
the most severe global health emergency since the 1918 Influenza outbreak. Depending …
[HTML][HTML] Discovering gene re-ranking efficiency and conserved gene-gene relationships derived from gene co-expression network analysis on breast cancer data
Systemic approaches are essential in the discovery of disease-specific genes, offering a
different perspective and new tools on the analysis of several types of molecular relationships, …
different perspective and new tools on the analysis of several types of molecular relationships, …
[HTML][HTML] Network-based stage-specific drug repurposing for Alzheimer's disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most
common type of dementia. With no disease-curing drugs available and an ever-growing AD-related …
common type of dementia. With no disease-curing drugs available and an ever-growing AD-related …
Response to anti-α4β7 blockade in patients with ulcerative colitis is associated with distinct mucosal gene expression profiles at baseline
Background Improving treatment outcomes with biological therapy is a demanding current
need for patients with inflammatory bowel disease. Discovery of pretreatment prognostic …
need for patients with inflammatory bowel disease. Discovery of pretreatment prognostic …
A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools
…, F Chatzinasiou, CM Lill, MM Bourdakou… - Database, 2014 - academic.oup.com
The publicly available online database MelGene provides a comprehensive, regularly
updated, collection of data from genetic association studies in cutaneous melanoma (CM), …
updated, collection of data from genetic association studies in cutaneous melanoma (CM), …
PathWalks: Identifying pathway communities using a disease-related map of integrated information
Motivation Understanding the underlying biological mechanisms and respective interactions
of a disease remains an elusive, time consuming and costly task. Computational …
of a disease remains an elusive, time consuming and costly task. Computational …
[HTML][HTML] Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood
MM Bourdakou, R Fernández-Ginés, A Cuadrado… - Redox Biology, 2023 - Elsevier
Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder and the most
common cause of cognitive decline. The alarming epidemiological features of Alzheimer's …
common cause of cognitive decline. The alarming epidemiological features of Alzheimer's …