User profiles for MARILENA M. BOURDAKOU

Marilena Bourdakou

Postdoctoral Fellow and Visiting Scientist at Cyprus Institute of Neurology and Genetics
Verified email at cing.ac.cy
Cited by 409

Systems bioinformatics: increasing precision of computational diagnostics and therapeutics through network-based approaches

…, K Sokratous, MM Bourdakou… - Briefings in …, 2019 - academic.oup.com
Abstract Systems Bioinformatics is a relatively new approach, which lies in the intersection
of systems biology and classical bioinformatics. It focuses on integrating information across …

Bioinformatics methods in drug repurposing for Alzheimer's disease

JC Siavelis, MM Bourdakou… - Briefings in …, 2016 - academic.oup.com
Alarming epidemiological features of Alzheimer’s disease impose curative treatment rather
than symptomatic relief. Drug repurposing, that is reappraisal of a substance’s indications …

[HTML][HTML] Generalized linear models provide a measure of virulence for specific mutations in SARS-CoV-2 strains

…, M Zachariou, G Minadakis, MM Bourdakou… - PLoS …, 2021 - journals.plos.org
This study aims to highlight SARS-COV-2 mutations which are associated with increased or
decreased viral virulence. We utilize genetic data from all strains available from GISAID and …

Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19

M Tomazou, MM Bourdakou, G Minadakis… - Briefings in …, 2021 - academic.oup.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is undeniably
the most severe global health emergency since the 1918 Influenza outbreak. Depending …

[HTML][HTML] Discovering gene re-ranking efficiency and conserved gene-gene relationships derived from gene co-expression network analysis on breast cancer data

MM Bourdakou, EI Athanasiadis, GM Spyrou - Scientific reports, 2016 - nature.com
Systemic approaches are essential in the discovery of disease-specific genes, offering a
different perspective and new tools on the analysis of several types of molecular relationships, …

[HTML][HTML] Network-based stage-specific drug repurposing for Alzheimer's disease

K Savva, M Zachariou, MM Bourdakou, N Dietis… - Computational and …, 2022 - Elsevier
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most
common type of dementia. With no disease-curing drugs available and an ever-growing AD-related …

Response to anti-α4β7 blockade in patients with ulcerative colitis is associated with distinct mucosal gene expression profiles at baseline

M Gazouli, N Dovrolis, MM Bourdakou… - Inflammatory Bowel …, 2022 - academic.oup.com
Background Improving treatment outcomes with biological therapy is a demanding current
need for patients with inflammatory bowel disease. Discovery of pretreatment prognostic …

A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools

…, F Chatzinasiou, CM Lill, MM Bourdakou… - Database, 2014 - academic.oup.com
The publicly available online database MelGene provides a comprehensive, regularly
updated, collection of data from genetic association studies in cutaneous melanoma (CM), …

PathWalks: Identifying pathway communities using a disease-related map of integrated information

E Karatzas, M Zachariou, MM Bourdakou… - …, 2020 - academic.oup.com
Motivation Understanding the underlying biological mechanisms and respective interactions
of a disease remains an elusive, time consuming and costly task. Computational …

[HTML][HTML] Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood

MM Bourdakou, R Fernández-Ginés, A Cuadrado… - Redox Biology, 2023 - Elsevier
Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder and the most
common cause of cognitive decline. The alarming epidemiological features of Alzheimer's …