Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

L Apetoh, F Ghiringhelli, A Tesniere, M Obeid, C Ortiz… - Nature medicine, 2007 - nature.com
Conventional cancer treatments rely on radiotherapy and chemotherapy. Such treatments
supposedly mediate their effects via the direct elimination of tumor cells. Here we show that …

Consensus guidelines for the detection of immunogenic cell death

…, E Vacchelli, S Adjemian, P Agostinis, L Apetoh… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

K Sakuishi, L Apetoh, JM Sullivan, BR Blazar… - Journal of Experimental …, 2010 - rupress.org
The immune response plays an important role in staving off cancer; however, mechanisms
of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

…, P Antas, A Antebi, Z Antón, T Anwar, L Apetoh… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered the …

Calreticulin exposure dictates the immunogenicity of cancer cell death

…, A Tesniere, F Ghiringhelli, GM Fimia, L Apetoh… - Nature medicine, 2007 - nature.com
Anthracyclin-treated tumor cells are particularly effective in eliciting an anticancer immune
response, whereas other DNA-damaging agents such as etoposide and mitomycin C do not …

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

F Ghiringhelli, L Apetoh, A Tesniere, L Aymeric, Y Ma… - Nature medicine, 2009 - nature.com
The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs),
which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–…

[HTML][HTML] Immunological aspects of cancer chemotherapy

L Zitvogel, L Apetoh, F Ghiringhelli… - Nature reviews …, 2008 - nature.com
Accumulating evidence indicates that the innate and adaptive immune systems make a
crucial contribution to the antitumour effects of conventional chemotherapy-based and …

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy

L Apetoh, F Ghiringhelli, A Tesniere… - Immunological …, 2007 - Wiley Online Library
For the last four decades, the treatment of cancer has relied on four treatment modalities,
namely surgery, radiotherapy, cytotoxic chemotherapy, and hormonotherapy. Most of these …

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide

…, C Engblom, MJ Pittet, A Schlitzer, F Ginhoux, L Apetoh… - science, 2013 - science.org
Cyclophosphamide is one of several clinically important cancer drugs whose therapeutic
efficacy is due in part to their ability to stimulate antitumor immune responses. Studying mouse …

5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell–dependent antitumor immunity

…, M Bruchard, A Chevriaux, F Martin, L Apetoh… - Cancer research, 2010 - AACR
Myeloid-derived suppressor cells (MDSC) accumulate in the spleen and tumor bed during
tumor growth. They contribute to the immune tolerance of cancer notably by inhibiting the …