Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Conventional cancer treatments rely on radiotherapy and chemotherapy. Such treatments
supposedly mediate their effects via the direct elimination of tumor cells. Here we show that …
supposedly mediate their effects via the direct elimination of tumor cells. Here we show that …
Consensus guidelines for the detection of immunogenic cell death
…, E Vacchelli, S Adjemian, P Agostinis, L Apetoh… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
K Sakuishi, L Apetoh, JM Sullivan, BR Blazar… - Journal of Experimental …, 2010 - rupress.org
The immune response plays an important role in staving off cancer; however, mechanisms
of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or …
of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
…, P Antas, A Antebi, Z Antón, T Anwar, L Apetoh… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered the …
Since then, this topic has received increasing attention, and many scientists have entered the …
Calreticulin exposure dictates the immunogenicity of cancer cell death
…, A Tesniere, F Ghiringhelli, GM Fimia, L Apetoh… - Nature medicine, 2007 - nature.com
Anthracyclin-treated tumor cells are particularly effective in eliciting an anticancer immune
response, whereas other DNA-damaging agents such as etoposide and mitomycin C do not …
response, whereas other DNA-damaging agents such as etoposide and mitomycin C do not …
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
F Ghiringhelli, L Apetoh, A Tesniere, L Aymeric, Y Ma… - Nature medicine, 2009 - nature.com
The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs),
which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–…
which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–…
[HTML][HTML] Immunological aspects of cancer chemotherapy
L Zitvogel, L Apetoh, F Ghiringhelli… - Nature reviews …, 2008 - nature.com
Accumulating evidence indicates that the innate and adaptive immune systems make a
crucial contribution to the antitumour effects of conventional chemotherapy-based and …
crucial contribution to the antitumour effects of conventional chemotherapy-based and …
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy
L Apetoh, F Ghiringhelli, A Tesniere… - Immunological …, 2007 - Wiley Online Library
For the last four decades, the treatment of cancer has relied on four treatment modalities,
namely surgery, radiotherapy, cytotoxic chemotherapy, and hormonotherapy. Most of these …
namely surgery, radiotherapy, cytotoxic chemotherapy, and hormonotherapy. Most of these …
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Cyclophosphamide is one of several clinically important cancer drugs whose therapeutic
efficacy is due in part to their ability to stimulate antitumor immune responses. Studying mouse …
efficacy is due in part to their ability to stimulate antitumor immune responses. Studying mouse …
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell–dependent antitumor immunity
…, M Bruchard, A Chevriaux, F Martin, L Apetoh… - Cancer research, 2010 - AACR
Myeloid-derived suppressor cells (MDSC) accumulate in the spleen and tumor bed during
tumor growth. They contribute to the immune tolerance of cancer notably by inhibiting the …
tumor growth. They contribute to the immune tolerance of cancer notably by inhibiting the …