[HTML][HTML] Emerging roles of focal adhesion kinase in cancer

YL Tai, LC Chen, TL Shen - BioMed research international, 2015 - hindawi.com
Focal adhesion kinase (FAK) is a cytoplasmic nonreceptor tyrosine kinase that enables
activation by growth factor receptors or integrins in various types of human cancers. The kinase-…

[PDF][PDF] Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21. 3

…, SP Hao, HY Li, MH Wang, LP Liao, LC Chen… - The American Journal of …, 2009 - cell.com
Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy closely associated with
genetic factors and Epstein-Barr virus infection. To identify the common genetic variants linked …

Tumour inflammasome‐derived IL‐1β recruits neutrophils and improves local recurrence‐free survival in EBV‐induced nasopharyngeal carcinoma

LC Chen, LJ Wang, NM Tsang, DM Ojcius… - EMBO molecular …, 2012 - embopress.org
Inflammasomes sense infection and cellular damage and are critical for triggering inflammation
through IL‐1β production. In carcinogenesis, inflammasomes may have contradictory …

[HTML][HTML] A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma

LC Chen, CC Chen, Y Liang, NM Tsang, YS Chang… - Modern Pathology, 2011 - Elsevier
Tumor necrosis factor alpha (TNFα) is an inflammatory cytokine that is present in the
microenvironment of many tumors and is known to promote tumor progression. To examine how …

[HTML][HTML] Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis

…, SN Yuan, HP Li, JT Chen, HR Shieh, YJ Chen… - Scientific reports, 2016 - nature.com
The inflammasome adaptor protein, ASC, contributes to both innate immune responses and
inflammatory diseases via self-oligomerization, which leads to the activation of the protease, …

[HTML][HTML] Pretreatment with a heat-killed probiotic modulates the NLRP3 inflammasome and attenuates colitis-associated colorectal cancer in mice

…, YJ Chen, AK Chung, DM Ojcius, YS Chang, LC Chen - Nutrients, 2019 - mdpi.com
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Inflammation
contributes to cancer development and inflammatory bowel disease is an important risk …

[HTML][HTML] Lactic acid fermentation is required for NLRP3 inflammasome activation

HC Lin, YJ Chen, YH Wei, TF Liu, KY Huang… - Frontiers in …, 2021 - frontiersin.org
Activation of the Nod-like receptor 3 (NLRP3) inflammasome is important for activation of
innate immune responses, but improper and excessive activation can cause inflammatory …

[HTML][HTML] The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal …

LC Chen, IC Chung, C Hsueh, NM Tsang… - Cell Death & …, 2010 - nature.com
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) mediates antiapoptotic activity in
part by inducing downstream antiapoptotic genes. To systematically identify hnRNP K targets …

[HTML][HTML] PKCα mediated induction of miR-101 in human hepatoma HepG2 cells

…, KW Leong, LC Chen, HC Chen, SJ Chen… - Journal of biomedical …, 2010 - Springer
Background Protein Kinase C (PKC) is a serine/threonine kinase that involved in controlling
of many cellular processes such as cell proliferation and differentiation. We have observed …

Aberrant methylation impairs low density lipoprotein receptor‐related protein 1B tumor suppressor function in gastric cancer

…, CY Lu, YW Leu, CS Wang, LC Chen… - Genes …, 2010 - Wiley Online Library
DNA methylation plays a significant role in tumor progression. In this study, we used CpG
microarray and differential methylation hybridization approaches to identify low density …