[HTML][HTML] Emerging roles of focal adhesion kinase in cancer
YL Tai, LC Chen, TL Shen - BioMed research international, 2015 - hindawi.com
Focal adhesion kinase (FAK) is a cytoplasmic nonreceptor tyrosine kinase that enables
activation by growth factor receptors or integrins in various types of human cancers. The kinase-…
activation by growth factor receptors or integrins in various types of human cancers. The kinase-…
[PDF][PDF] Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21. 3
…, SP Hao, HY Li, MH Wang, LP Liao, LC Chen… - The American Journal of …, 2009 - cell.com
Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy closely associated with
genetic factors and Epstein-Barr virus infection. To identify the common genetic variants linked …
genetic factors and Epstein-Barr virus infection. To identify the common genetic variants linked …
Tumour inflammasome‐derived IL‐1β recruits neutrophils and improves local recurrence‐free survival in EBV‐induced nasopharyngeal carcinoma
Inflammasomes sense infection and cellular damage and are critical for triggering inflammation
through IL‐1β production. In carcinogenesis, inflammasomes may have contradictory …
through IL‐1β production. In carcinogenesis, inflammasomes may have contradictory …
[HTML][HTML] A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma
LC Chen, CC Chen, Y Liang, NM Tsang, YS Chang… - Modern Pathology, 2011 - Elsevier
Tumor necrosis factor alpha (TNFα) is an inflammatory cytokine that is present in the
microenvironment of many tumors and is known to promote tumor progression. To examine how …
microenvironment of many tumors and is known to promote tumor progression. To examine how …
[HTML][HTML] Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis
…, SN Yuan, HP Li, JT Chen, HR Shieh, YJ Chen… - Scientific reports, 2016 - nature.com
The inflammasome adaptor protein, ASC, contributes to both innate immune responses and
inflammatory diseases via self-oligomerization, which leads to the activation of the protease, …
inflammatory diseases via self-oligomerization, which leads to the activation of the protease, …
[HTML][HTML] Pretreatment with a heat-killed probiotic modulates the NLRP3 inflammasome and attenuates colitis-associated colorectal cancer in mice
…, YJ Chen, AK Chung, DM Ojcius, YS Chang, LC Chen - Nutrients, 2019 - mdpi.com
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Inflammation
contributes to cancer development and inflammatory bowel disease is an important risk …
contributes to cancer development and inflammatory bowel disease is an important risk …
[HTML][HTML] Lactic acid fermentation is required for NLRP3 inflammasome activation
HC Lin, YJ Chen, YH Wei, TF Liu, KY Huang… - Frontiers in …, 2021 - frontiersin.org
Activation of the Nod-like receptor 3 (NLRP3) inflammasome is important for activation of
innate immune responses, but improper and excessive activation can cause inflammatory …
innate immune responses, but improper and excessive activation can cause inflammatory …
[HTML][HTML] The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal …
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) mediates antiapoptotic activity in
part by inducing downstream antiapoptotic genes. To systematically identify hnRNP K targets …
part by inducing downstream antiapoptotic genes. To systematically identify hnRNP K targets …
[HTML][HTML] PKCα mediated induction of miR-101 in human hepatoma HepG2 cells
…, KW Leong, LC Chen, HC Chen, SJ Chen… - Journal of biomedical …, 2010 - Springer
Background Protein Kinase C (PKC) is a serine/threonine kinase that involved in controlling
of many cellular processes such as cell proliferation and differentiation. We have observed …
of many cellular processes such as cell proliferation and differentiation. We have observed …
Aberrant methylation impairs low density lipoprotein receptor‐related protein 1B tumor suppressor function in gastric cancer
…, CY Lu, YW Leu, CS Wang, LC Chen… - Genes …, 2010 - Wiley Online Library
DNA methylation plays a significant role in tumor progression. In this study, we used CpG
microarray and differential methylation hybridization approaches to identify low density …
microarray and differential methylation hybridization approaches to identify low density …