Reactive oxygen species (ROS) are produced continuously in living cells as a by-product of
respiration and other metabolic activity. Some ROS may react with DNA, and in some cases …

Four series of intercalating, square-planar Pt (II) complexes derived from the ligands 2, 2'-bipyridine,
2, 2': 6', 2"-terpyridine, 1, 10-phenanthroline, and3, 4, 17, 8-tetramethyl-l, 10-…

The design of improved mixed poisons of topoisomerases (topo) I and II is an important aim
of cancer chemotherapy. 1, 2 Structural information on both enzymes is now available, 3-5 …

Echinomycin is a peptide antibiotic which binds strongly to double-helical DNA up to a limit
of approximately one molecule per five base-pairs. There is no detectable interaction with …

Four classes of diacridines, joined at the 9-position by linker chains of varying length, rigidity,
and polarity, were evaluated for DNA-binding properties and antitumor activity. Diacridines …

The kinetics of dissociation of calf thymus DNA complexes of the new intercalating antitumor
drug iV-[2-(dimethylamino) ethyl]-9-aminoacridine-4-carboxamide (5) and selected …

The structure of the complex formed between d(CGTACG) 2 and the antitumor agent 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide
has been solved to a resolution of 1.6 …

We have synthesized a series of bis(9-aminoacridine-4-carboxamides) linked via the 9-position
with neutral flexible alkyl chains, charged flexible polyamine chains, and a semirigid …

A series of DNA-targeted aniline mustards have been prepared, and their chemical reactivity
and in vitro and in vivo cytotoxicity have been evaluated and compared with that of the …

This report examines the mechanism of action of DNA‐binding anticancer drugs that involve
electron transfer and oxidative stress, and primarily focuses on neglected issues …