Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

K Yamamoto, A Venida, J Yano, DE Biancur… - Nature, 2020 - nature.com
Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion
include impaired antigen presentation caused by mutations or loss of heterozygosity of the …

[PDF][PDF] Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1

K Yamamoto, T Sato, T Matsui, M Sato, T Okada… - Developmental cell, 2007 - cell.com
Metazoans express three unfolded protein response transducers (IRE1, PERK, and ATF6)
ubiquitously to cope with endoplasmic reticulum (ER) stress. ATF6 is an ER membrane-bound …

[PDF][PDF] Neurons release serine to support mRNA translation in pancreatic cancer

RS Banh, DE Biancur, K Yamamoto, ASW Sohn… - Cell, 2020 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) tumors have a nutrient-poor, desmoplastic, and
highly innervated tumor microenvironment. Although neurons can release stimulatory factors …

ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum

Y Adachi, K Yamamoto, T Okada, H Yoshida… - Cell structure and …, 2008 - jstage.jst.go.jp
Eukaryotic cells cope with endoplasmic reticulum (ER) stress by activating the unfolded protein
response (UPR), a coordinated system of transcriptional and translational controls, which …

Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis-Acting Elements ERSE, UPRE and ERSE-II

K Yamamoto, H Yoshida, K Kokame… - Journal of …, 2004 - academic.oup.com
ATF6 and XBP1 are transcription factors activated specifically in response to endoplasmic
reticulum (ER) stress. Three cis-acting elements capable of binding to ATF6, XBP1 or both …

Loss of 5‐hydroxymethylcytosine is accompanied with malignant cellular transformation

Y Kudo, K Tateishi, K Yamamoto, S Yamamoto… - Cancer …, 2012 - Wiley Online Library
Dysregulated DNA methylation followed by abnormal gene expression is an epigenetic
hallmark in cancer. DNA methylation is catalyzed by DNA methyltransferases, and the aberrant …

Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα

K Yamamoto, K Tateishi, Y Kudo, T Sato… - …, 2014 - academic.oup.com
Genetic mutations in pancreatic ductal adenocarcinoma (PDAC) with critical roles have been
well examined. The recent discovery of alterations in genes encoding histone modifiers …

A large volume of visceral adipose tissue leads to severe acute pancreatitis

…, H Isayama, T Tsujino, R Nagano, K Yamamoto… - Journal of …, 2011 - Springer
Background Obesity plays an important role in acute pancreatitis. Assuming that the volume
of visceral adipose tissue (VAT) directly influences the severity of acute pancreatitis, we …

Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines

…, N Yoshida, R Yasumoto, S Wada, K Yamamoto… - Urology, 2000 - Elsevier
Objectives. To investigate the antitumor effects of Scutellariae radix and its components
baicalein, baicalin, and wogonin on human bladder cancer cell lines (KU-1 and EJ-1) and a …

Induction of liver steatosis and lipid droplet formation in ATF6α-knockout mice burdened with pharmacological endoplasmic reticulum stress

K Yamamoto, K Takahara, S Oyadomari… - Molecular biology of …, 2010 - Am Soc Cell Biol
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates homeostatic
responses collectively termed the unfolded protein response. Among the three principal …