[HTML][HTML] Epigenetics meets radiation biology as a new approach in cancer treatment
Cancer is a disease that results from both genetic and epigenetic changes. In recent decades,
a number of people have investigated the disparities in gene expression resulting from …
a number of people have investigated the disparities in gene expression resulting from …
Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer
SC Glöckner, M Dhir, JM Yi, KE McGarvey… - Cancer research, 2009 - AACR
We have used a gene expression array–based strategy to identify the methylation of tissue
factor pathway inhibitor 2 (TFPI2), a potential tumor suppressor gene, as a frequent event in …
factor pathway inhibitor 2 (TFPI2), a potential tumor suppressor gene, as a frequent event in …
[HTML][HTML] Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer …
…, YJ Hyun, AX Zhen, SJ Cho, MJ Ahn, JM Yi… - … & molecular medicine, 2019 - nature.com
Luteolin, a dietary flavone, modulates various signaling pathways involved in carcinogenesis.
In this study, we investigated the molecular mechanism that underlies the apoptotic effects …
In this study, we investigated the molecular mechanism that underlies the apoptotic effects …
[HTML][HTML] Particulate matter induces inflammatory cytokine production via activation of NFκB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin
YS Ryu, KA Kang, MJ Piao, MJ Ahn, JM Yi, YM Hyun… - Redox biology, 2019 - Elsevier
Particulate matter (PM) increases levels of pro-inflammatory cytokines, but its effects on the
skin remain largely unknown. We investigated the signal transduction pathway and …
skin remain largely unknown. We investigated the signal transduction pathway and …
[HTML][HTML] Comparing the DNA hypermethylome with gene mutations in human colorectal cancer
…, W Chen, L Cope, SC Glöckner, H Suzuki, JM Yi… - PLoS …, 2007 - journals.plos.org
We have developed a transcriptome-wide approach to identify genes affected by promoter
CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By …
CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By …
Genomic and epigenomic integration identifies a prognostic signature in colon cancer
JM Yi, M Dhir, L Van Neste, SR Downing… - Clinical Cancer …, 2011 - AACR
Purpose: The importance of genetic and epigenetic alterations maybe in their aggregate
role in altering core pathways in tumorigenesis. Experimental Design: Merging genome-wide …
role in altering core pathways in tumorigenesis. Experimental Design: Merging genome-wide …
Novel methylation biomarker panel for the early detection of pancreatic cancer
JM Yi, AA Guzzetta, VJ Bailey, SR Downing… - Clinical Cancer …, 2013 - AACR
Purpose: Pancreatic cancer is the fourth leading cause of cancer deaths and there currently
is no reliable modality for the early detection of this disease. Here, we identify cancer-…
is no reliable modality for the early detection of this disease. Here, we identify cancer-…
[HTML][HTML] Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
TA Chan, S Glockner, JM Yi, W Chen… - PLoS …, 2008 - journals.plos.org
Background The identification and characterization of tumor suppressor genes has
enhanced our understanding of the biology of cancer and enabled the development of new …
enhanced our understanding of the biology of cancer and enabled the development of new …
Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors
JM Yi, HC Tsai, SC Glöckner, S Lin, JE Ohm… - Cancer research, 2008 - AACR
Much recent effort has focused on identifying and characterizing cellular markers that
distinguish tumor propagating cells (TPC) from more differentiated progeny. We report here an …
distinguish tumor propagating cells (TPC) from more differentiated progeny. We report here an …
[HTML][HTML] Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications
YS Ryu, KA Kang, MJ Piao, MJ Ahn, JM Yi… - … & molecular medicine, 2019 - nature.com
Ambient air particulate matter (PM) induces senescence in human skin cells. However, the
underlying mechanisms remain largely unknown. We investigated how epigenetic regulatory …
underlying mechanisms remain largely unknown. We investigated how epigenetic regulatory …