Prevalence and prognostic and predictive relevance of PRAME in breast cancer

P Doolan, M Clynes, S Kennedy, JP Mehta… - Breast cancer research …, 2008 - Springer
Preferentially expressed antigen of melanoma (PRAME) has been described as a potential
candidate for immunotherapeutic targeting. However, the prognostic and predictive …

Effect of the metabolic environment at key stages of follicle development in cattle: focus on steroid biosynthesis

SW Walsh, JP Mehta, PA McGettigan… - Physiological …, 2012 - journals.physiology.org
Cellular mechanisms that contribute to low estradiol concentrations produced by the preovulatory
ovarian follicle in cattle with a compromised metabolic status are largely unknown. To …

[HTML][HTML] Investigation of the molecular profile of basal cell carcinoma using whole genome microarrays

…, J McMorrow, P Doolan, E McKiernan, JP Mehta… - Molecular cancer, 2006 - Springer
Background Skin cancer accounts for 1/3 of all newly diagnosed cancer. Although seldom
fatal, basal cell carcinoma (BCC) is associated with severe disfigurement and morbidity. BCC …

[HTML][HTML] miRNAs as biomarkers of therapeutic response to HER2-targeted treatment in breast cancer: a systematic review

…, O O'Donovan, EA McNeela, JP Mehta… - … and Biophysics Reports, 2024 - Elsevier
Breast cancer is the most common type of lethal cancer in women globally. Women have a 1
in 8 chance of developing breast cancer in their lifetime. Among the four primary molecular …

[HTML][HTML] Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma

…, M Halasz, T Schwarzl, D Fey, K Iljin, JP Mehta… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Despite intensive study, many mysteries remain about the MYCN oncogene's functions.
Here we focus on MYCN's role in neuroblastoma, the most common extracranial childhood …

Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion

S Rani, JP Mehta, N Barron, P Doolan… - Cellular physiology and …, 2006 - karger.com
Background and aims: Recently, thioredoxin-interacting protein (Txnip) expression has been
implicated in a number of cellular events associated with diabetes, with increased Txnip …

Drug metabolism-related genes as potential biomarkers: analysis of expression in normal and tumour breast tissue

…, H Joyce, E Kenny, J Prakash Mehta… - Breast cancer research …, 2008 - Springer
The complex role of drug metabolism-related enzymes and their possible influence in cancer
development, treatment and outcome has not yet been completely elucidated. There is …

Feasibility and relevance of global expression profiling of gene transcripts in serum from breast cancer patients using whole genome microarrays and quantitative RT …

L O'DRISCOLL, E Kenny, JP Mehta… - Cancer genomics & …, 2008 - cgp.iiarjournals.org
Background: Previous studies, by ourselves and others, have indicated that gene transcripts
are detectable extracellularly. Advancing on this work, in order to investigate the feasibility …

Endometrial response of beef heifers on day 7 following insemination to supraphysiological concentrations of progesterone associated with superovulation

…, F Carter, S di Francesco, JP Mehta… - Physiological …, 2012 - journals.physiology.org
Ovarian stimulation is a routine procedure in assisted reproduction to stimulate the growth of
multiple follicles in naturally single-ovulating species including cattle and humans. The aim …

Software and tools for microarray data analysis

JP Mehta, S Rani - Gene Expression Profiling: Methods and Protocols, 2011 - Springer
A typical microarray experiment results in series of images, depending on the experimental
design and number of samples. Software analyses the images to obtain the intensity at each …