Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

S Chiba, M Baghdadi, H Akiba, H Yoshiyama… - Nature …, 2012 - nature.com
The mechanisms by which tumor microenvironments modulate nucleic acid–mediated innate
immunity remain unknown. Here we identify the receptor TIM-3 as key in circumventing the …

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

M Jinushi, S Chiba, H Yoshiyama… - Proceedings of the …, 2011 - National Acad Sciences
Recent evidence has unveiled the critical role of tumor cells with stem cell activities in
tumorigenicity and drug resistance, but how tumor microenvironments regulate cancer stem/…

Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells

…, E Kawanishi, R Yoshida, H Yoshiyama - Journal of virology, 2013 - Am Soc Microbiol
Epstein-Barr virus (EBV), a human gammaherpesvirus, establishes a lifelong latent infection
in B lymphocytes and epithelial cells following primary infection. Several lines of evidence …

[HTML][HTML] Epstein-Barr Virus (EBV)-associated gastric carcinoma

…, A Nanbo, J Nishikawa, M Jinushi, H Yoshiyama - Viruses, 2012 - mdpi.com
The ubiquitous Epstein-Barr virus (EBV) is associated with several human tumors, which
include lymphoid and epithelial malignancies. It is known that EBV persistently infects the …

Urease Plays an Important Role in the Chemotactic Motility of Helicobacter pylori in a Viscous Environment

H Nakamura, H Yoshiyama, H Takeuchi… - Infection and …, 1998 - Am Soc Microbiol
Helicobacter pylori exhibits chemotactic responses to urea, flurofamide, acetohydroxamic
acid, and sodium bicarbonate. In buffer, the chemotactic activities of a urease-positive strain …

[PDF][PDF] TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance

…, S Nagai, H Akiba, M Foretz, H Yoshiyama… - Immunity, 2013 - cell.com
Phagocytosis of apoptotic cells by myeloid cells has been implicated in the maintenance of
immune homeostasis. In this study, we found that T cell immunoglobulin- and mucin domain-…

A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori

T Okamoto, H Yoshiyama, T Nakazawa… - Journal of …, 2002 - academic.oup.com
Reports on the isolation of amoxicillin-resistant Helicobacter pylori are increasing worldwide,
which may cause serious problems in eradication therapy. To elucidate the mechanism of …

[HTML][HTML] Clinical importance of Epstein–Barr virus-associated gastric cancer

J Nishikawa, H Iizasa, H Yoshiyama, K Shimokuri… - Cancers, 2018 - mdpi.com
Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy
caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric …

[HTML][HTML] Unique mechanism of Helicobacter pylori for colonizing the gastric mucus

H Yoshiyama, T Nakazawa - Microbes and infection, 2000 - Elsevier
Helicobacter pylori is a human gastric pathogen causing chronic infection. Urease and motility
using flagella are essential factors for its colonization. Urease of H. pylori exists both on …

Epstein-Barr virus infection of human gastric carcinoma cells: implication of the existence of a new virus receptor different from CD21

H Yoshiyama, S Imai, N Shimizu, K Takada - Journal of virology, 1997 - Am Soc Microbiol
Recombinant Epstein-Barr virus (EBV) with a selectable marker successfully infected the
human gastric carcinoma cell lines AGS, MKN28, and MKN74. Following incubation in …